A Phase 1 study of GDC‐0134, a dual leucine zipper kinase inhibitor, in ALS
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51491
Abstract: Dual leucine zipper kinase (DLK), which regulates the c‐Jun N‐terminal kinase pathway involved in axon degeneration and apoptosis following neuronal injury, is a potential therapeutic target in amyotrophic lateral sclerosis (ALS). This first‐in‐human study investigated… read more here.
Keywords: dual leucine; zipper kinase; kinase; gdc 0134 ... See more keywords
Regulation of dual leucine zipper kinase activity through its interaction with calcineurin.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2021.109953
Abstract: Hyperglycemia enhancing the intracellular levels of reactive oxygen species (ROS) contributes to dysfunction and progressive loss of beta cells and thereby to diabetes mellitus. The oxidation sensitive calcium/calmodulin dependent phosphatase calcineurin promotes pancreatic beta cell… read more here.
Keywords: dlk; calcineurin; kinase; dual leucine ... See more keywords
Dual Leucine Zipper Kinase Is Constitutively Active in the Adult Mouse Brain and Has Both Stress-Induced and Homeostatic Functions
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21144849
Abstract: Dual leucine zipper kinase (DLK, Map3k12) is an axonal protein that governs the balance between degeneration and regeneration through its downstream effectors c-jun N-terminal kinase (JNK) and phosphorylated c-jun (p-c-Jun). In peripheral nerves DLK is… read more here.
Keywords: dlk; leucine zipper; jun; kinase ... See more keywords
Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.20725
Abstract: The PKR-like endoplasmic reticulum kinase (PERK) arm of the Integrated Stress Response (ISR) is implicated in neurodegenerative disease, although the regulators and consequences of PERK activation following neuronal injury are poorly understood. Here we show… read more here.
Keywords: leucine zipper; kinase; dual leucine; perk ... See more keywords