Dual-molecular barcode sequencing detects rare variants in tumor and cell free DNA in plasma
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-60361-3
Abstract: Conventional next generation sequencing analysis has provided important insights into cancer genetics. However, the detection of rare (low allele fraction) variants remains difficult because of the error-prone nucleotide changes derived from sequencing/PCR errors. To eliminate… read more here.
Keywords: dna; barcode; molecular barcode; barcode sequencing ... See more keywords
A chemically encoded timer for dual molecular delivery at tailored ranges and concentrations.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical communications"
DOI: 10.1039/c8cc03253j
Abstract: Spatiotemporal control of molecular distribution is much in demand in many fields of chemistry. To address this goal, we exploit a low molecular weight branched self-immolative architecture, which acts as a triggerable chemically encoded timer… read more here.
Keywords: chemically encoded; encoded timer; molecular delivery; dual molecular ... See more keywords
Dual molecular tweezers extending from a nanohoop.
Sign Up to like & getrecommendations! Published in 2024 at "Chemical communications"
DOI: 10.1039/d4cc03196b
Abstract: The field of nanohoops is mature enough that synthetic protocols exists to tune their size, composition (incorporation of heteroaromatic building blocks), connectivity (para versus meta linkages), and solubility in different media (hydrophobic versus hydrophilic). Here,… read more here.
Keywords: extending nanohoop; molecular tweezers; dual molecular; tweezers extending ... See more keywords