Interaction potential of the dual orexin receptor antagonist ACT-541468 with CYP3A4 and food: results from two interaction studies
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-018-2559-5
Abstract: PurposeACT-541468 is a novel dual orexin receptor antagonist (DORA) under development for the treatment of insomnia. In vitro studies suggested a significant role of CYP3A4 in ACT-541468 metabolism and an impact on CYP3A4 activity.MethodsSubsequently, two… read more here.
Keywords: act; act 541468; dual orexin; interaction ... See more keywords
Dual orexin receptor antagonist induces changes in core body temperature in rats after exercise
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-54826-3
Abstract: Hypothalamic orexin neurons are involved in various physiological functions, including thermoregulation. The orexinergic system has been considered as a potent mediator of the exercise response. The present study describes how the antagonization of the orexinergic… read more here.
Keywords: receptor antagonist; orexin; core body; dual orexin ... See more keywords
Dual orexin receptor antagonists for the treatment of insomnia: systematic review and network meta-analysis
Sign Up to like & getrecommendations! Published in 2022 at "Arquivos de Neuro-Psiquiatria"
DOI: 10.1055/s-0043-1768667
Abstract: Abstract Background Several randomized clinical trials (RCTs) have shown that dual orexin receptor antagonists (DORAs) are effective in the treatment of chronic insomnia. However, the superiority of one particular DORA over the others remains unclear.… read more here.
Keywords: receptor antagonists; meta analysis; orexin receptor; dual orexin ... See more keywords
Dual orexin antagonist DORA-22 normalized sleep homeostatic drive, enhanced GABAergic inhibition and suppressed seizures after traumatic brain injury.
Sign Up to like & getrecommendations! Published in 2022 at "Sleep"
DOI: 10.1093/sleep/zsac238
Abstract: STUDY OBJECTIVES Traumatic brain injury (TBI) can result in posttraumatic epilepsy (PTE) and sleep disturbances. We hypothesized that treatment with sleep aids after TBI can ameliorate PTE. METHODS CD-1 mice underwent controlled cortical impact (CCI),… read more here.
Keywords: month; treatment; dual orexin; week ... See more keywords
The dual orexin receptor antagonist, DORA‐22, lowers histamine levels in the lateral hypothalamus and prefrontal cortex without lowering hippocampal acetylcholine
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.14055
Abstract: Chronic insomnia is defined as a persistent difficulty with sleep initiation maintenance or non‐restorative sleep. The therapeutic standard of care for this condition is treatment with gamma‐aminobutyric acid (GABA)A receptor modulators, which promote sleep but… read more here.
Keywords: dual orexin; receptor; hypothalamus prefrontal; lateral hypothalamus ... See more keywords
Daridorexant: A New Dual Orexin Receptor Antagonist for Insomnia
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Pharmacy Technology"
DOI: 10.1177/87551225221112546
Abstract: Objective: To review the safety, efficacy, and tolerability of daridorexant in treating insomnia characterized by difficulties with sleep onset and/or sleep maintenance in adult patients. Data Sources: A literature search was performed through PubMed using… read more here.
Keywords: receptor antagonist; orexin; insomnia; dual orexin ... See more keywords
Different doses of dual orexin receptor antagonists in primary insomnia: a Bayesian network analysis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1175372
Abstract: Background: Systematic comparisons of the doses of the Food and Drug Administration (FDA)-approved dual orexin receptor antagonists (DORAs) for people with insomnia are limited. Methods: PubMed, Embase, Cochrane Library, and Clinicaltrials. gov were systematically searched… read more here.
Keywords: receptor antagonists; orexin receptor; certainty; dual orexin ... See more keywords
A Comprehensive Review of Daridorexant, a Dual-Orexin Receptor Antagonist as New Approach for the Treatment of Insomnia
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27186041
Abstract: Insomnia affects 4.4–4.8% of the world’s population, but because the effect of hypnotic drugs is limited and may cause harmful side-effects, scientists are turning their attention to developing drugs that act on the orexin system.… read more here.
Keywords: comprehensive review; receptor antagonist; orexin; dual orexin ... See more keywords
UPLC-MS/MS Based Identification and Quantification of a Novel Dual Orexin Receptor Antagonist in Plasma Samples by Validated SWGTOX Guidelines
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DOI: 10.3390/toxics11020109
Abstract: Lemborexant (LEM) is a novel dual orexin receptor antagonist (DORA), recently approved for the treatment of insomnia. As with other DORAs, LEM has potential of abuse and therefore placed in Schedule IV class by the… read more here.
Keywords: quantification; receptor antagonist; novel dual; plasma ... See more keywords