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Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.09.008
Abstract: Glioblastoma (GBM) is the deadliest primary brain tumor that is highly resistant to current treatments. Polo-like kinase 1 (PLK1) and signal transducer and activator of transcription 3 (STAT3) are highly expressed in gliomas, especially GBM.…
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Keywords:
plk1;
apoptosis;
dual plk1;
inhibition ... See more keywords
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Published in 2019 at "Translational Oncology"
DOI: 10.1016/j.tranon.2019.09.013
Abstract: Simultaneous inhibition of multiple molecular targets is an established strategy to improve the continuance of clinical response to therapy. Here, we screened 49 molecules with dual nanomolar inhibitory activity against BRD4 and PLK1, best classified…
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Keywords:
plk1;
plk1 brd4;
dual plk1;
small molecule ... See more keywords