Dual reactivity of 1-chloro- and 1-bromo-3,5-dinitrobenzenes in aromatic nucleophilic substitution
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DOI: 10.1016/j.mencom.2017.03.018
Abstract: Aromatic nucleophilic substitution reactions in 1-halo-3,5-dinitrobenzenes (where the halogen is bromine or chlorine) can occur with replacement of either a nitro group or a halogen atom, depending on the nature of anionic nucleophile Nu– as… read more here.
Keywords: nucleophilic substitution; chloro bromo; dual reactivity; aromatic nucleophilic ... See more keywords
Phenanthrene-Extended Phenazine Dication: An Electrochromic Conformational Switch Presenting Dual Reactivity
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DOI: 10.1021/jacs.2c00493
Abstract: The synthesis and isolation of one of the few examples of a π-extended diamagnetic phenazine dication have been achieved by oxidizing a phenanthrene-based dihydrophenazine precursor. The resulting dication was isolated and fully characterized, highlighting an… read more here.
Keywords: phenanthrene; dication; dual reactivity; reactivity ... See more keywords
Dual reactivity disulfide bridging reagents; enabling new approaches to antibody fragment bioconjugation
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DOI: 10.1039/d2sc04531a
Abstract: Disulfide bridging, also known as disulfide stapling, is a powerful strategy for the construction of site-selective protein bioconjugates. Here we describe the first examples of a new class of such reagents, containing a ‘stable-labile’ design.… read more here.
Keywords: reactivity disulfide; bioconjugation; bridging reagents; disulfide bridging ... See more keywords