C‐Nitrosothioformamide: A Donor Template for Dual Release of HNO and H2S
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200101
Abstract: C‐Nitrosothioformamide was demonstrated to be a donor template for dual release of HNO and COS triggered by a retro‐Diels‐Alder reaction. COS is an H2S precursor in the presence of carbonic anhydrase. This process produces HNO… read more here.
Keywords: template dual; dual release; hno h2s; h2s ... See more keywords
The urinary cortisol metabolome in patients with adrenal insufficiency: Dual-release hydrocortisone is less deleterious than conventional hydrocortisone therapy
Sign Up to like & getrecommendations! Published in 2018 at "Annales d'Endocrinologie"
DOI: 10.1016/j.ando.2018.04.004
Abstract: Introduction Oral once-daily dual-release hydrocortisone (DR-HC) replacement therapy provides a more physiological cortisol profile than conventional thrice-daily (TID) therapy and has demonstrated improved metabolic profile among patients with adrenal insufficiency (AI). The mechanisms by which… read more here.
Keywords: dual release; cortisol; patients adrenal; hydrocortisone ... See more keywords
Hydrolyzable emulsions as dual release platform for hydrophobic drugs and DNA
Sign Up to like & getrecommendations! Published in 2023 at "Chemical Communications"
DOI: 10.1039/d3cc00888f
Abstract: Several challenges need to be overcome when applying nucleic acids as therapeutic agents. We developed a new way to control the onset of the release of cholesterol-conjugated oligonucleotides with a simple, versatile, and cheap platform.… read more here.
Keywords: platform; dual release; release platform; release ... See more keywords
Dual-release hydrocortisone vs conventional glucocorticoids in adrenal insufficiency
Sign Up to like & getrecommendations! Published in 2019 at "Endocrine Connections"
DOI: 10.1530/ec-19-0176
Abstract: Background Dual-release hydrocortisone (DR-HC) improves metabolism in patients with adrenal insufficiency. The aims of this study were to compare the cardiovascular and metabolic effects of conventional glucocorticoids (GCs) vs. DR-HC and of high vs. low… read more here.
Keywords: adrenal insufficiency; release hydrocortisone; conventional glucocorticoids; dual release ... See more keywords
Dual Release Model to Evaluate Dissolution Profiles from Swellable Drug Polyelectrolyte Matrices.
Sign Up to like & getrecommendations! Published in 2020 at "Current drug delivery"
DOI: 10.2174/1567201817666200512093115
Abstract: BACKGROUND Mathematical modeling in modified drug release is an important tool that allows predicting the release rate of drugs in their surrounding environment and elucidates the transport mechanisms involved in the process. OBJECTIVE The aim… read more here.
Keywords: dual release; release; model; drug release ... See more keywords