Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors
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DOI: 10.7554/elife.81856
Abstract: CRISPR interference (CRISPRi) enables programmable, reversible, and titratable repression of gene expression (knockdown) in mammalian cells. Initial CRISPRi-mediated genetic screens have showcased the potential to address basic questions in cell biology, genetics, and biotechnology, but… read more here.
Keywords: sgrna libraries; maximizing crispri; crispri; crispri efficacy ... See more keywords