Design, synthesis, and evaluation of dual‐target inhibitors for the treatment of Alzheimer's disease
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DOI: 10.1002/ardp.202300693
Abstract: Aβ1−42 and acetylcholinesterase (AChE) are two key therapeutic targets for Alzheimer's disease (AD). The purpose of this study is to develop a dual‐target inhibitor that inhibits both of these targets by fusing the chemical structure… read more here.
Keywords: alzheimer disease; synthesis evaluation; design synthesis; dual target ... See more keywords
Pyrimidine scaffold dual‐target kinase inhibitors for cancer diseases: A review on design strategies, synthetic approaches, and structure–activity relationship (2018‒2023)
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DOI: 10.1002/ardp.202400163
Abstract: Cancer, the second leading cause of death globally, causes a significant threat to life. Despite advancements in the treatment of cancer, persistent challenges include severe side effects and the emergence of acquired drug resistance. Additionally,… read more here.
Keywords: drug; cancer; design strategies; dual target ... See more keywords
New approach of delivering cytotoxic drugs towards CAIX expressing cells: A concept of dual-target drugs.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2016.10.037
Abstract: Carbonic anhydrase IX (CAIX) is a hypoxia-regulated and tumor-specific protein that maintains the pH balance of cells. Targeting CAIX might be a valuable approach for specific delivery of cytotoxic drugs, thereby reducing normal tissue side-effects.… read more here.
Keywords: dual target; caix expressing; target; cytotoxic drugs ... See more keywords
Design, synthesis and evaluation of azaacridine derivatives as dual-target EGFR and Src kinase inhibitors for antitumor treatment.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.05.006
Abstract: Overexpression of EGFR is often associated with advanced stage disease and poor prognosis. In certain cancers, Src works synergistically with EGFR to promote proliferation, survival, invasion and metastasis. Development of dual-target drugs against EGFR and… read more here.
Keywords: dual target; kinase inhibitors; egfr src; target ... See more keywords
Dual-target kinase drug design: Current strategies and future directions in cancer therapy.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.112025
Abstract: Protein kinases are well-known to orchestrate the activation of signaling cascades in response to extracellular and intracellular stimuli to control cell proliferation and survival. The perturbation of such kinases by some mutation or abnormal protein… read more here.
Keywords: dual target; target kinase; chemistry; drug ... See more keywords
Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112991
Abstract: Fungal infections have become a serious medical problem due to the high infection rate and the frequent emergence of drug resistance. Squalene epoxidase (SE) and 14α-demethylase (CYP51) are considered as the important antifungal targets, they… read more here.
Keywords: dual target; naphthylamide derivatives; target; derivatives dual ... See more keywords
Dual‐target screening of bioactive components from traditional Chinese medicines by hollow fiber‐based ligand fishing combined with liquid chromatography–mass spectrometry
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2017.06.001
Abstract: &NA; A novel strategy was developed for dual‐target screening of bioactive components from traditional Chinese medicines (TCMs). This strategy was based on the use of low‐cost microporous hollow fibers filled with target enzymes as baits… read more here.
Keywords: dual target; screening bioactive; target; ligand ... See more keywords
Distinguishable Magnetic Reporter Coordination with Buoyancy-Magnetism Separation for Immobilization-Free Dual-Target Electrochemical Immunosensing.
Sign Up to like & getrecommendations! Published in 2024 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.3c05391
Abstract: Simultaneous sensitive and precise determination of multibiomarkers is of great significance for improving detection efficiency, reducing diagnosis and treatment expenses, and elevating survival rates. However, the development of simple and portable biosensors for simultaneous determination… read more here.
Keywords: free dual; distinguishable magnetic; dual target; cea afp ... See more keywords
Rational Design of N-Methylcarbamoylguanidinyl Derivatives as Highly Potent Dual-Target Chitin Hydrolase Inhibitors for Retarding Growth of Pest Insects.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c07605
Abstract: Chitin degradation is a vital process for the growth of insects. Chitin hydrolase OfChtI and β-N-acetylhexosaminidase OfHex1 are two key enzymes involved in hydrolyzing the chitin of insects' cuticles. Thus, they are considered promising targets… read more here.
Keywords: chitin; growth; insects; dual target ... See more keywords
Design, Synthesis, and Biological Evaluation of Dual-Target COX-2/CYP51 Inhibitors for the Treatment of Fungal Infectious Diseases.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00878
Abstract: The design of novel dual-target (COX-2/CYP51) inhibitors was proposed in the study, and three series of compounds were constructed though the pathway of skeleton screening and combination; their molecular structures were synthesized and evaluated. Most… read more here.
Keywords: target cox; cyp51 inhibitors; cox cyp51; dual target ... See more keywords
Systematic Investigation of Dual-Target-Directed Ligands
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DOI: 10.1021/acs.jmedchem.4c00838
Abstract: Multitarget-directed ligands (MTDLs) are compounds rationally designed to affect multiple targets, aiming for a better therapeutic profile. For over 20 years, MTDLs have garnered increasing attention, the idea being that their full potential would have… read more here.
Keywords: target directed; chemistry; directed ligands; systematic investigation ... See more keywords