New approach of delivering cytotoxic drugs towards CAIX expressing cells: A concept of dual-target drugs.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2016.10.037
Abstract: Carbonic anhydrase IX (CAIX) is a hypoxia-regulated and tumor-specific protein that maintains the pH balance of cells. Targeting CAIX might be a valuable approach for specific delivery of cytotoxic drugs, thereby reducing normal tissue side-effects.… read more here.
Keywords: dual target; caix expressing; target; cytotoxic drugs ... See more keywords
Design, synthesis and evaluation of azaacridine derivatives as dual-target EGFR and Src kinase inhibitors for antitumor treatment.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.05.006
Abstract: Overexpression of EGFR is often associated with advanced stage disease and poor prognosis. In certain cancers, Src works synergistically with EGFR to promote proliferation, survival, invasion and metastasis. Development of dual-target drugs against EGFR and… read more here.
Keywords: dual target; kinase inhibitors; egfr src; target ... See more keywords
Dual-target kinase drug design: Current strategies and future directions in cancer therapy.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.112025
Abstract: Protein kinases are well-known to orchestrate the activation of signaling cascades in response to extracellular and intracellular stimuli to control cell proliferation and survival. The perturbation of such kinases by some mutation or abnormal protein… read more here.
Keywords: dual target; target kinase; chemistry; drug ... See more keywords
Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112991
Abstract: Fungal infections have become a serious medical problem due to the high infection rate and the frequent emergence of drug resistance. Squalene epoxidase (SE) and 14α-demethylase (CYP51) are considered as the important antifungal targets, they… read more here.
Keywords: dual target; naphthylamide derivatives; target; derivatives dual ... See more keywords
Dual‐target screening of bioactive components from traditional Chinese medicines by hollow fiber‐based ligand fishing combined with liquid chromatography–mass spectrometry
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2017.06.001
Abstract: &NA; A novel strategy was developed for dual‐target screening of bioactive components from traditional Chinese medicines (TCMs). This strategy was based on the use of low‐cost microporous hollow fibers filled with target enzymes as baits… read more here.
Keywords: dual target; screening bioactive; target; ligand ... See more keywords
Rational Design of N-Methylcarbamoylguanidinyl Derivatives as Highly Potent Dual-Target Chitin Hydrolase Inhibitors for Retarding Growth of Pest Insects.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c07605
Abstract: Chitin degradation is a vital process for the growth of insects. Chitin hydrolase OfChtI and β-N-acetylhexosaminidase OfHex1 are two key enzymes involved in hydrolyzing the chitin of insects' cuticles. Thus, they are considered promising targets… read more here.
Keywords: chitin; growth; insects; dual target ... See more keywords
Design, Synthesis, and Biological Evaluation of Dual-Target COX-2/CYP51 Inhibitors for the Treatment of Fungal Infectious Diseases.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00878
Abstract: The design of novel dual-target (COX-2/CYP51) inhibitors was proposed in the study, and three series of compounds were constructed though the pathway of skeleton screening and combination; their molecular structures were synthesized and evaluated. Most… read more here.
Keywords: target cox; cyp51 inhibitors; cox cyp51; dual target ... See more keywords
Application of nitroimidazole-carbobane-modified phenylalanine derivatives as dual-target boron carriers in boron neutron capture therapy.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.9b00898
Abstract: Boron neutron capture therapy (BNCT) has received extensive attention as non-invasive cell-level oncotherapy for treating solid cancer tumors. However, boron-containing drugs such as L-boronophenylalanine (BPA) and sodium borocaptate (BSH) have low boron content and/or poor… read more here.
Keywords: dual target; boron neutron; neutron capture; application ... See more keywords
Activity Prediction of Small Molecule Inhibitors for Antirheumatoid Arthritis Targets Based on Artificial Intelligence.
Sign Up to like & getrecommendations! Published in 2020 at "ACS combinatorial science"
DOI: 10.1021/acscombsci.0c00169
Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune disease, which is compared to "immortal cancer" in industry. Currently, SYK, BTK, and JAK are the three major targets of protein tyrosine kinase for this disease. According to… read more here.
Keywords: dual target; integrated model; target; model ... See more keywords
The relative length of dual-target conjugated on iron oxide nanoparticles plays a role in brain glioma targeting
Sign Up to like & getrecommendations! Published in 2017 at "RSC Advances"
DOI: 10.1039/c7ra02102j
Abstract: The application of superparamagnetic iron oxide nanoparticles as a magnetic resonance (MR) nanoprobe for brain glioma is limited by the insufficient specificity and accumulation at the tumor site. To increase brain glioma-targeting specificity and improve… read more here.
Keywords: dual target; relative length; brain glioma; target ... See more keywords
Dietary stigmastane-type saponins as promising dual-target directed inhibitors of SARS-CoV-2 proteases: a structure-based screening
Sign Up to like & getrecommendations! Published in 2021 at "RSC Advances"
DOI: 10.1039/d1ra05976a
Abstract: Vernonia amygdalina derived phytochemicals as potential dual-target directed inhibitors of SARS-CoV-2 proteases from computational study perspective. read more here.
Keywords: dual target; target directed; inhibitors sars; cov proteases ... See more keywords