Sentinel Lymph Node Characterization with a Dual-Targeted Molecular Ultrasound Contrast Agent
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Imaging and Biology"
DOI: 10.1007/s11307-017-1109-3
Abstract: PurposeThe purpose of this study was to assess the performance of molecular ultrasound with dual-targeted microbubbles to detect metastatic disease in the sentinel lymph nodes (SLNs) in swine model of naturally occurring melanoma. The SLN… read more here.
Keywords: contrast agent; dual targeted; slns; molecular ultrasound ... See more keywords
A Novel Method to Construct Dual-targeted Magnetic Nanoprobes by Modular Assembling
Sign Up to like & getrecommendations! Published in 2020 at "Colloids and Surfaces A: Physicochemical and Engineering Aspects"
DOI: 10.1016/j.colsurfa.2020.125339
Abstract: Abstract Magnetic nanoparticle is an important branch of nanomaterials, especially magnetic iron oxide (Fe3O4) nanoparticles have attracted widespread attention due to the fact that they can be used not only as high-sensitivity magnetic resonance contrast… read more here.
Keywords: cd3 fe3o4; magnetic nanoprobes; fe3o4; method construct ... See more keywords
Saporin‐loaded CD44 and EGFR dual‐targeted nanogels for potent inhibition of metastatic breast cancer in vivo
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.01.040
Abstract: &NA; Metastasis poses a long‐standing treatment challenge for many cancers including breast cancer. Once spreading out, cell‐selective delivery of drug appears especially critical. Here, we report on epidermal growth factor receptor and CD44 dual‐targeted hyaluronic… read more here.
Keywords: egfr cd44; breast cancer; cd44 ngs; cancer ... See more keywords
Lactobionic/Folate Dual-Targeted Amphiphilic Maltodextrin-Based Micelles for Targeted Codelivery of Sulfasalazine and Resveratrol to Hepatocellular Carcinoma.
Sign Up to like & getrecommendations! Published in 2018 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.8b00428
Abstract: In this study, promising approaches of dual-targeted micelles and drug-polymer conjugation were combined to enable injection of poorly soluble anticancer drugs together with site-specific drug release. Ursodeoxycholic acid (UDCA) as a hepatoprotective agent was grafted… read more here.
Keywords: based micelles; targeted micelles; drug; amphiphilic maltodextrin ... See more keywords
Synthesis of Multiarm Peptide Dendrimers for Dual Targeted Thrombolysis
Sign Up to like & getrecommendations! Published in 2020 at "ACS Macro Letters"
DOI: 10.1021/acsmacrolett.0c00054
Abstract: Current thrombolytic agents generally possess low specificity and pose a high risk of intracranial hemorrhage. Here, various generations of multiarm polylactic acid–polyglutamic acid peptide dendri... read more here.
Keywords: peptide; synthesis multiarm; dendrimers dual; multiarm peptide ... See more keywords
A novel tumor and mitochondria dual-targeted photosensitizer showing ultra-efficient photodynamic anticancer activities.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c8cc09456j
Abstract: We designed and synthesized a simple, but highly effective photosensitizer (G-Mito-Pc), which can precisely target the mitochondria of epidermal growth factor receptor (EGFR)-overexpressing cancer cells, to achieve dual targeting function at both cell and organelle… read more here.
Keywords: novel tumor; targeted photosensitizer; mitochondria dual; tumor mitochondria ... See more keywords
A DNA and mitochondria dual-targeted photosensitizer for two-photon-excited bioimaging and photodynamic therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d1bm01969d
Abstract: Biological substrates and organelle multi-targeted photosensitizers for ultra-efficient cancer treatment through photodynamic therapy (PDT) are highly desirable. Herein, a multiple pyridinium-anchored photosensitizer containing the triphenylamine unit, TPA-2PI, has been designed and utilized for DNA and… read more here.
Keywords: dual targeted; two photon; tpa 2pi; photodynamic therapy ... See more keywords
Morpholine-modified permethyl β-cyclodextrin supramolecular nanoparticles for precise dual-targeted imaging.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc00735a
Abstract: Possessing dual-targeted agents toward the lysosome and cancer cells, a ternary supramolecular assembly was constructed by a morpholine-modified permethyl β-cyclodextrin, sulfonated porphyrin, and folic acid-modified chitosan via multivalent interactions. As compared with free porphyrin, the… read more here.
Keywords: dual targeted; permethyl cyclodextrin; morpholine modified; cyclodextrin supramolecular ... See more keywords
Dual Targeted Therapy for the Management of Inflammatory Bowel Disease
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Gastroenterology"
DOI: 10.1097/mcg.0000000000001583
Abstract: The burden of inflammatory bowel disease (IBD) is increasing globally and imposes a high morbidity in patients with IBD. Advances have been made in medical management of IBD with the advent of novel therapies such… read more here.
Keywords: inflammatory; management; inflammatory bowel; dual targeted ... See more keywords
Design and Testing of Dual-Targeted Gd3N@C80-Containing Glioblastoma Theranostics
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Nanomaterials"
DOI: 10.1155/2019/1242930
Abstract: The majority of the malignant brain tumors are gliomas with glioblastoma being the most common and aggressive type. Due to its extreme infiltrative nature and higher occurrence frequency, finding new glioblastoma therapeutics and diagnostics is… read more here.
Keywords: dual targeted; gd3n c80; glioblastoma; design testing ... See more keywords
Abstract 5337: Design, synthesis and evaluation of dual-targeted mEGFR and AURK inhibitors as anticancer agents
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5337
Abstract: Mutant epidermal growth factor receptor (mEGFR) inhibitors constitute the recommended therapy for mEGFR-positive cancers. However, resistance has developed to mEGFR inhibitors due to newer mutations within the enzyme pocket and redundant signaling pathways that bypass… read more here.
Keywords: dual targeted; aurk inhibitors; megfr; synthesis ... See more keywords