Improving the Potency of Cancer Immunotherapy by Dual Targeting of IDO1 and DNA
Sign Up to like & getrecommendations! Published in 2018 at "ChemMedChem"
DOI: 10.1002/cmdc.201700666
Abstract: Herein we report the first exploration of a dual‐targeting drug design strategy to improve the efficacy of small‐molecule cancer immunotherapy. New hybrids of indoleamine 2,3‐dioxygenase 1 (IDO1) inhibitors and DNA alkylating nitrogen mustards that respectively target… read more here.
Keywords: dual targeting; ido1 dna; cancer immunotherapy;
Dual Targeting of G9a and DNA Methyltransferase‐1 for the Treatment of Experimental Cholangiocarcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology"
DOI: 10.1002/hep.31642
Abstract: Cholangiocarcinoma (CCA) is a devastating disease often detected at advanced stages when surgery cannot be performed. Conventional and targeted systemic therapies perform poorly, and therefore effective drugs are urgently needed. Different epigenetic modifications occur in… read more here.
Keywords: dual targeting; methyltransferase; cholangiocarcinoma; dna methyltransferase ... See more keywords
A dual‐targeting near‐infrared biomimetic drug delivery system for HBV treatment
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28312
Abstract: Hepatitis B virus (HBV) infection is a serious global public health threat. It remains elusive to achieve a functional HBV cure with currently available antivirals. Herein, a photo‐responsive delivery vehicle composed of Nd3+‐sensitized core–shell upconversion… read more here.
Keywords: system; dual targeting; hbv; drug delivery ... See more keywords
Dual Targeting Smart Drug Delivery System for Multimodal Synergistic Combination Cancer Therapy with Reduced Cardiotoxicity.
Sign Up to like & getrecommendations! Published in 2021 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2021.06.016
Abstract: This study first reports the development of a smart drug delivery system (DDS) for multimodal synergistic cancer therapy combining chemo-photothermal-starvation approaches. A magnetic photothermal agent was synthesized by preparing iron oxide (IO) nanoparticles (NPs) with… read more here.
Keywords: delivery system; dual targeting; drug delivery; drug ... See more keywords
Design, synthesis, and biological evaluation of dual targeting inhibitors of histone deacetylase 6/8 and bromodomain BRPF1.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112338
Abstract: Histone modifying proteins, specifically histone deacetylases (HDACs) and bromodomains, have emerged as novel promising targets for anticancer therapy. In the current work, based on available crystal structures and docking studies, we designed dual inhibitors of… read more here.
Keywords: design synthesis; evaluation dual; biological evaluation; dual targeting ... See more keywords
Discovery of novel tubulin/HDAC dual-targeting inhibitors with strong antitumor and antiangiogenic potency.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113790
Abstract: A novel series of cis-diphenylethene and benzophenone derivatives as tubulin/HDAC dual-targeting inhibitors were designed and synthesized. Among them, compound 28g exhibited the most potent antiproliferative activities against six different human cancer cell lines, 28g could… read more here.
Keywords: targeting inhibitors; tubulin hdac; dual targeting; antitumor antiangiogenic ... See more keywords
Dual-targeting nanoparticles with core-crosslinked and pH/redox-bioresponsive properties for enhanced intracellular drug delivery.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of colloid and interface science"
DOI: 10.1016/j.jcis.2019.01.021
Abstract: Multifunctional nanoparticles (NPs) with high blood-stability, tumor-targeting ability, and stimuli-bioresponsive drug release behaviors are urgently demanded. Herein, folic acid (FA) and galactose (GAL) functionalized, core-crosslinked NPs (CC NPs) with dual-targeting and pH/redox-bioresponsive properties were developed… read more here.
Keywords: pmgdp; dual targeting; delivery; drug ... See more keywords
Environmentally responsive dual-targeting nanotheranostics for overcoming cancer multidrug resistance
Sign Up to like & getrecommendations! Published in 2019 at "Science Bulletin"
DOI: 10.1016/j.scib.2019.04.019
Abstract: Abstract The development of multiple drug resistance (MDR) to chemotherapy and subsequent treatment failures are major obstacles in cancer therapy. An attractive option for combating MDR is inhibiting the expression of P-glycoprotein (P-gp) in tumor… read more here.
Keywords: environmentally responsive; dual targeting; cancer; mdr ... See more keywords
Iron(III) Coordinated Theranostic Polyprodrug with Sequential Receptor-Mitochondria Dual Targeting and T1-Weighted Magnetic Resonance Imaging Potency for Effective and Precise Chemotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c00302
Abstract: The sequential cancer cell receptor and mitochondria dual-targeting single delivery agent deliver chemotherapeutic drug effectively and precisely at the targeted site has become a promising strategy to enhance the drug efficacy and suppressions of cancer… read more here.
Keywords: receptor mitochondria; dual targeting; mitochondria dual; receptor ... See more keywords
Facile Fabrication of Nanoparticles with Dual Targeting Ligands for Precise Hepatocellular Carcinoma Therapy in Vitro and in Vivo.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.0c00327
Abstract: Efficient hepatocellular carcinoma (HCC) therapy remains a significant challenge due to the unsatisfactory targeting efficiency of nanoparticles (NPs) with either a passive targeting or a single active targeting property. Although a dual targeting mechanism-based strategy… read more here.
Keywords: hepatocellular carcinoma; therapy; hcc; vitro vivo ... See more keywords
Construction of Red Fluorescent Dual Targeting Mechanically Interlocked Molecules for Live Cancer Cell Specific Lysosomal Staining and Multicolor Cellular Imaging.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02114
Abstract: We have designed and synthesized red fluorescent mechanically interlocked molecules with dual targeting functionality for live cancer cell specific active targeting followed by selective internalization and imaging of malignant lysosomes along with real-time tracking, 3D,… read more here.
Keywords: live cancer; red fluorescent; dual targeting; cancer cell ... See more keywords