Dual receptor T cells mediate effective antitumor immune responses via increased recognition of tumor antigens
Sign Up to like & getrecommendations! Published in 2023 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-006472
Abstract: Background Discovery that ~16% of T cells naturally co-express two T-cell receptor (TCR) clonotypes prompts examining the role of dual TCR cells in immune functions. Methods Using TCRα-reporter transgenic mice, enabling unambiguous identification of single-TCR and… read more here.
Keywords: tcr; dual tcr; tcr cells; antitumor immune ... See more keywords
scRNA+ TCR-seq revealed dual TCR T cells antitumor response in the TME of NSCLC
Sign Up to like & getrecommendations! Published in 2024 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2024-009376
Abstract: The intricate origins, subsets, and characteristics of TCR (T Cell Receptor) s, along with the mechanisms underpinning the antitumor response of tumor-infiltrating T lymphocytes within the tumor microenvironment (TME) remain enigmatic. Recently, the advent of… read more here.
Keywords: scrna tcr; response; dual tcr; tumor ... See more keywords