The Novel Dual Topoisomerase Inhibitor P8-D6 Shows Anti-myeloma Activity In Vitro and In Vivo
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-21-0119
Abstract: P8-D6 is a novel dual inhibitor of human topoisomerase I (TOP1) and II (TOP2) with broad pro-apoptotic antitumor activity. NCI-60 screening revealed markedly improved cytotoxicity of P8-D6 against solid and leukemia cell lines compared with… read more here.
Keywords: topoisomerase; myeloma; novel dual; dual topoisomerase ... See more keywords
High Antitumor Activity of the Dual Topoisomerase Inhibitor P8-D6 in Breast Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers14010002
Abstract: Simple Summary Despite significant advancement in therapeutic strategies, breast cancers remain the most prevalent type of cancer in terms of incidence and mortality worldwide. Therefore, new alternative therapies have become an urgent clinical need. The… read more here.
Keywords: cancer; breast cancer; apoptosis; dual topoisomerase ... See more keywords