Baicalein inhibits acinar‐to‐ductal metaplasia of pancreatic acinal cell AR42J via improving the inflammatory microenvironment
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26293
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers. Recent research has demonstrated that chronic pancreatitis (CP) is associated with an increased risk of PDAC, partly due to acinar‐to‐ductal metaplasia (ADM). Baicalein has… read more here.
Keywords: ductal metaplasia; baicalein; acinar ductal; cell ... See more keywords
κB-Ras and Ral GTPases regulate acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-17226-0
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is associated with high mortality and therapy resistance. Here, we show that low expression of κB-Ras GTPases is frequently detected in PDAC and correlates with higher histologic grade. In a model… read more here.
Keywords: ductal metaplasia; pancreatitis; ras; acinar ductal ... See more keywords
Acinar-to-Ductal Metaplasia: Bridging the Gap Between Cellular Plasticity and Treatment Innovations in Chronic Pancreatitis.
Sign Up to like & getrecommendations! Published in 2025 at "Pancreas"
DOI: 10.1097/mpa.0000000000002588
Abstract: Chronic pancreatitis (CP) progressively destroys and fibroses the pancreatic parenchyma, ultimately impairing exocrine and endocrine functions. Acinar-to-ductal metaplasia (ADM), the transformation of acinar cells into duct-like cells, plays a critical role in the progression of… read more here.
Keywords: acinar ductal; chronic pancreatitis; plasticity; ductal metaplasia ... See more keywords
Pancreatic STAT5 activation promotes KrasG12D-induced and inflammation-induced acinar-to-ductal metaplasia and pancreatic cancer
Sign Up to like & getrecommendations! Published in 2024 at "Gut"
DOI: 10.1136/gutjnl-2024-332225
Abstract: Objective Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy because it is often diagnosed at a late-stage. Signal transducer and activator of transcription 5 (STAT5) is a transcription factor implicated in the progression of… read more here.
Keywords: acinar ductal; stat5; ductal metaplasia; stat5 activation ... See more keywords
Abstract 5777: Race as a predictive confounder in the rate of transdifferentiation and drug response in human pancreatic acinar ductal metaplasia
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5777
Abstract: Pancreatic diseases (chronic pancreatitis, type 2 diabetes, pancreatic cancer) disproportionately affect the Black/African American (AA) community in comparison to non-White Hispanics and Whites. Acinar to ductal metaplasia (ADM), the process by which pancreatic acinar cells… read more here.
Keywords: race; ductal metaplasia; rate; pancreatic acinar ... See more keywords
Abstract 3446: Acinar to ductal metaplasia is an evolutionary dead end and does not actively contribute to pancreas regeneration after damage
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-3446
Abstract: One of the major risk factors strongly associated with PDAC is pancreatitis and meta-analysis studies have revealed that inflammation of the pancreas increases the relative risk of developing pancreatic cancer by up to 13-fold. During… read more here.
Keywords: cancer; acinar ductal; damage; ductal metaplasia ... See more keywords
Neutrophil Infiltration and Acinar-ductal Metaplasia Are the Main Pathological Findings in Pembrolizumab-induced Pancreatitis
Sign Up to like & getrecommendations! Published in 2022 at "Internal Medicine"
DOI: 10.2169/internalmedicine.9565-22
Abstract: The histopathological findings of immune checkpoint inhibitor (ICI)-induced pancreatitis have rarely been reported. A 56-year-old man with squamous cell carcinoma of the lung with bone metastasis was being treated with pembrolizumab, an anti-programmed cell death… read more here.
Keywords: infiltration acinar; ductal metaplasia; pancreatitis; induced pancreatitis ... See more keywords
An integrated model of acinar to ductal metaplasia-related N7-methyladenosine regulators predicts prognosis and immunotherapy in pancreatic carcinoma based on digital spatial profiling
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.961457
Abstract: Acinar-to-ductal metaplasia (ADM) is a recently recognized, yet less well-studied, precursor lesion of pancreatic ductal adenocarcinoma (PDAC) developed in the setting of chronic pancreatitis. Through digital spatial mRNA profiling, we compared ADM and adjacent PDAC… read more here.
Keywords: immune cell; ductal metaplasia; digital spatial; model ... See more keywords