Ductular Reaction in Liver Diseases: Pathological Mechanisms and Translational Significances
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DOI: 10.1002/hep.30150
Abstract: Ductular reaction (DR) is characterized by the proliferation of reactive bile ducts induced by liver injuries. DR is pathologically recognized as bile duct hyperplasia and is commonly observed in biliary disorders. It can also be… read more here.
Keywords: ductular reaction; liver diseases; liver; diseases pathological ... See more keywords
Amelioration of Ductular Reaction by Stem Cell Derived Extracellular Vesicles in MDR2 Knockout Mice via Lethal‐7 microRNA
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30542
Abstract: Cholangiopathies are diseases that affect cholangiocytes, the cells lining the biliary tract. Liver stem cells (LSCs) are able to differentiate into all cells of the liver and possibly influence the surrounding liver tissue by secretion… read more here.
Keywords: extracellular vesicles; ductular reaction; cell derived; stem cell ... See more keywords
Mast Cells Regulate Ductular Reaction and Intestinal Inflammation in Cholestasis Through Farnesoid X Receptor Signaling
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DOI: 10.1002/hep.32028
Abstract: Cholestasis is characterized by increased total bile acid (TBA) levels, which are regulated by farnesoid X receptor (FXR)/FGF15. Patients with primary sclerosing cholangitis (PSC) typically present with inflammatory bowel disease (IBD). Mast cells (MCs) (i)… read more here.
Keywords: mast cells; cholestasis; ductular reaction; farnesoid receptor ... See more keywords
Mechanisms of ductular reaction in non-alcoholic steatohepatitis
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DOI: 10.3748/wjg.v28.i19.2088
Abstract: Non-alcoholic fatty liver disease (NAFLD) is a disease spectrum caused in part by insulin resistance and genetic predisposition. This disease is primarily characterized by excessive lipid accumulation in hepatocytes in the absence of alcohol abuse… read more here.
Keywords: disease; ductular reaction; non alcoholic; alcoholic steatohepatitis ... See more keywords
Differential expression of Lutheran/BCAM regulates biliary tissue remodeling in ductular reaction during liver regeneration
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DOI: 10.7554/elife.36572
Abstract: Under chronic or severe liver injury, liver progenitor cells (LPCs) of biliary origin are known to expand and contribute to the regeneration of hepatocytes and cholangiocytes. This regeneration process is called ductular reaction (DR), which… read more here.
Keywords: bcam regulates; biliary tissue; ductular reaction; regeneration ... See more keywords
β-Catenin-NF-κB-CFTR interactions in cholangiocytes regulate inflammation and fibrosis during ductular reaction
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DOI: 10.7554/elife.71310
Abstract: Expansion of biliary epithelial cells (BECs) during ductular reaction (DR) is observed in liver diseases including cystic fibrosis (CF), and associated with inflammation and fibrosis, albeit without complete understanding of underlying mechanism. Using two different… read more here.
Keywords: ductular reaction; catenin; inflammation fibrosis; fibrosis ... See more keywords