Lysis of human erythrocytes due to Piezo1-dependent cytosolic calcium overload as a mechanism of circulatory removal
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2407765121
Abstract: Significance Mature red blood cells (RBC) are enucleated, devoid of cell organelles, and incapable of translational activity. Yet, the RBC lifespan is remarkably consistent, and the molecular underpinnings of this apparently timely and targeted removal… read more here.
Keywords: due piezo1; calcium; human erythrocytes; lysis ... See more keywords
Hereditary Hemolytic Anemia Due to PIEZO1 Red Blood Cell Membrane Defect
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DOI: 10.1080/03630269.2024.2427187
Abstract: Abstract PIEZO1 (piezo-type mechanosensitive ion channel component 1) is a mechanosensitive ion channel protein. Gain-of-function variants in the PIEZO1 gene are known to cause dehydrated hereditary stomatocytosis (DHS) also termed hereditary xerocytosis. This is a… read more here.
Keywords: due piezo1; hereditary hemolytic; anemia; anemia due ... See more keywords