Duloxetine and Amitriptyline Reduce Neuropathic Pain by Inhibiting Primary Sensory Input to Spinal Dorsal Horn Neurons via α1- and α2-Adrenergic Receptors.
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DOI: 10.1021/acschemneuro.2c00780
Abstract: Antidepressants, such as duloxetine and amitriptyline, are effective for treating patients with chronic neuropathic pain. Inhibiting norepinephrine and serotonin transporters at presynaptic terminals raises extracellular concentrations of norepinephrine. The α1- and α2-adrenergic receptor agonists inhibit… read more here.
Keywords: duloxetine amitriptyline; effect; neuropathic pain; adrenergic receptors ... See more keywords
Comparing the efficacy and safety of duloxetine and amitriptyline in the treatment of fibromyalgia: overview of systematic reviews
Sign Up to like & getrecommendations! Published in 2020 at "Advances in Rheumatology"
DOI: 10.1186/s42358-020-00137-5
Abstract: Background Duloxetine and amitriptyline are antidepressants used in the treatment of fibromyalgia. In published systematic reviews, there is no agreement about which drug is more effective and safer. This study aimed to compare evidence of… read more here.
Keywords: evidence; treatment; duloxetine amitriptyline; treatment fibromyalgia ... See more keywords