Duodenal Layer Morphometry to Guide Duodenal Mucosal Resurfacing in Patients with and without Type 2 Diabetes Mellitus: Results of a Single-Center Intraluminal Imaging Pilot Study
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DOI: 10.1016/s0016-5085(17)32850-0
Abstract: Background: Endoscopic metabolic therapies, such as duodenal mucosal resurfacing (DMR) aimed at improving glycemic control in patients with Type 2 diabetes mellitus (T2DM) target the duodenal mucosa. It is unknown whether baseline differences in duodenal… read more here.
Keywords: duodenal mucosal; layer thickness; mucosal layer; mucosal ... See more keywords
Alterations of the duodenal mucosal microbiome in patients with metabolic dysfunction-associated steatotic liver disease
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DOI: 10.1038/s41598-024-59605-3
Abstract: Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease (NAFLD), is associated with altered gut microbiota; however, there has been a focus on fecal samples, which are not representative of the… read more here.
Keywords: microbiota; duodenal mucosal; liver disease; liver ... See more keywords
Development of Concentric Photothermal Ablation for Duodenal Mucosal Resurfacing
Sign Up to like & getrecommendations! Published in 2025 at "IEEE Transactions on Biomedical Engineering"
DOI: 10.1109/tbme.2025.3561260
Abstract: Objectives: Duodenal mucosal resurfacing (DMR) is a surgical method to treat type 2 diabetic mellitus. The current study developed laser-assisted photothermal DMR to ablate the duodenal mucosal surface in an instant and selective, compared with… read more here.
Keywords: mucosal; vivo; irradiation; photothermal ablation ... See more keywords
A look at duodenal mucosal resurfacing: Rationale for targeting the duodenum in type 2 diabetes
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DOI: 10.1111/dom.15533
Abstract: Affecting 5%–10% of the world population, type 2 diabetes (T2DM) is firmly established as one of the major health burdens of modern society. People with T2DM require long‐term therapies to reduce blood glucose, an approach… read more here.
Keywords: duodenum; type diabetes; targeting duodenum; duodenal mucosal ... See more keywords
Reduction of HbA1c in patients with type 2 diabetes following duodenal mucosal resurfacing: could other factors be at play?
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DOI: 10.1136/gutjnl-2020-320900
Abstract: We were interested to read the recent article by van Baar and colleagues that described an open-label phase II trial of endoscopic duodenal mucosal resurfacing (DMR) in the management of patients with type 2 diabetes… read more here.
Keywords: reduction; patients type; duodenal mucosal; type diabetes ... See more keywords
Duodenal mucosal resurfacing with a GLP-1 receptor agonist increases postprandial unconjugated bile acids in patients with insulin-dependent type 2 diabetes
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Physiology - Endocrinology and Metabolism"
DOI: 10.1152/ajpendo.00337.2021
Abstract: INTRODUCTION Duodenal Mucosal Resurfacing (DMR) is a new endoscopic ablation technique aimed at improving glycemia and metabolic control in patients with type 2 diabetes mellitus (T2DM). DMR appears to improve insulin resistance, which is the… read more here.
Keywords: bile acid; mucosal resurfacing; duodenal mucosal; bile ... See more keywords
Duodenal mucosal mitochondrial gene expression is associated with delayed gastric emptying in diabetic gastroenteropathy
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DOI: 10.1172/jci.insight.143596
Abstract: Hindered by a limited understanding of the mechanisms responsible for diabetic gastroenteropathy (DGE), management is symptomatic. We investigated the duodenal mucosal expression of protein-coding genes and microRNAs (miRNA) in DGE and related them to clinical… read more here.
Keywords: delayed gastric; duodenal mucosal; gastric emptying; dge ... See more keywords
Duodenal Mucosal Resurfacing Elicits Improvement in Glycemic and Hepatic Parameters in Type 2 Diabetes—One-Year Multicenter Study Results
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DOI: 10.2337/db18-1137-p
Abstract: Aims: Duodenal Mucosal Resurfacing (DMR) is a novel endoscopic procedure which has been shown to improve glycemic control at 6 months in type 2 diabetes (T2D). It is thought to exert insulin-sensitizing effects. DMR entails… read more here.
Keywords: duodenal mucosal; study; self; mucosal resurfacing ... See more keywords
The Impact of Duodenal Mucosal Vulnerability in the Development of Epigastric Pain Syndrome in Functional Dyspepsia
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DOI: 10.3390/ijms232213947
Abstract: An unidentified cause of functional dyspepsia (FD) is closely associated with medication resistance. Acid suppression is a traditional and preferential method for the treatment of FD, but the efficacy of this treatment varies between epigastric… read more here.
Keywords: epigastric pain; pain syndrome; duodenal mucosal; functional dyspepsia ... See more keywords
Duodenal mucosal ablation: An emerging therapeutic concept for metabolic dysfunction-associated fatty liver disease
Sign Up to like & getrecommendations! Published in 2025 at "World Journal of Gastroenterology"
DOI: 10.3748/wjg.v31.i28.109468
Abstract: Metabolic dysfunction-associated fatty liver disease (MAFLD) is currently the leading cause of end-stage liver disease and liver cancer in the world because of the obesity pandemic. Insulin resistance resulting from abdominal adiposity is the main… read more here.
Keywords: mucosal; mucosal ablation; gastroenterology; duodenal mucosal ... See more keywords