Spatiotemporal H2O2 flashes coordinate actin cytoskeletal remodeling and regulate cell migration and wound healing
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-62272-1
Abstract: Well-organized repair of damaged barrier epithelia is vital for infection control, resolution of inflammation, and enduring physical protection. Cysteine thiol and methionine oxidation are connected to cytoskeletal rearrangements in cell migration and wound healing, but… read more here.
Keywords: duox2; h2o2; migration; cell migration ... See more keywords
Correlation of DUOX2 residual enzymatic activity with phenotype in congenital hypothyroidism caused by biallelic DUOX2 defects.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical genetics"
DOI: 10.1111/cge.14065
Abstract: DUOX2 is the most frequently mutated gene in patients with congenital hypothyroidism (CH) in China. However, no reliable genotype-phenotype relationship has been found in patients with DUOX2 mutations. In this study, DUOX2 mutations were screened… read more here.
Keywords: hypothyroidism; enzymatic activity; duox2 residual; activity ... See more keywords
Calcium-dependent dual oxidase 2 is a novel source of reactive oxygen species implicated in glomerular mesangial cell fibrotic response to angiotensin II and glucose
Sign Up to like & getrecommendations! Published in 2024 at "Physiology"
DOI: 10.1152/physiol.2024.39.s1.2124
Abstract: The vasoactive peptide angiotensin II (Ang II) and hyperglycemia contribute to the initiation and the progression of glomerular fibrosis via activation of glomerular mesangial cells (MCs) and subsequent extracellular matrix expansion. We have previously shown… read more here.
Keywords: duox2; physiology; fibrotic injury; response ... See more keywords
CRISPR/Cas9-mediated modification of the extreme C-terminus impairs PDGF-stimulated activity of Duox2
Sign Up to like & getrecommendations! Published in 2018 at "Biological Chemistry"
DOI: 10.1515/hsz-2017-0229
Abstract: Abstract Duox2 belongs to the large family of NADPH-oxidase enzymes that are implicated in immune response, vasoregulation, hormone synthesis, cell growth and differentiation via the regulated synthesis of H2O2 and reactive oxygen species. We and… read more here.
Keywords: pdgf stimulated; stimulated activity; crispr cas9; activity ... See more keywords
TCN1 Drives Malignant Progression of Pancreatic Cancer Through STAT4-Mediated Transcriptional Activation of the DUOX2/ROS Signaling Axis
Sign Up to like & getrecommendations! Published in 2025 at "Cancers"
DOI: 10.3390/cancers17203300
Abstract: Simple Summary Pancreatic ductal adenocarcinoma is one of the deadliest cancers, and new biomarkers and treatment targets are urgently needed. We found that the protein transcobalamin 1 (TCN1) is markedly increased in pancreatic tumors and… read more here.
Keywords: duox2; tcn1; progression; pancreatic cancer ... See more keywords