G-quadruplex and duplex DNA binding studies of novel Ruthenium(II) complexes containing ascididemin ligands.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2019.03.021
Abstract: In this paper, three new Ruthenium(II) polypyridyl complexes containing ascididemin (ASC) as main ligand have been synthesized and characterized. Their interactions with different G-quadruplex (Htelo, c-myc and c-kit) (Htelo: human telomeric DNA, c-myc: cellular-myelocytomatosis viral… read more here.
Keywords: ruthenium; duplex dna; dna; quadruplex duplex ... See more keywords
Structural modification of nonspecific thiazole orange for ligand-DNA interaction study: Understanding the ligand recognition selectivity towards G4-DNA over duplex-DNA
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Luminescence"
DOI: 10.1016/j.jlumin.2020.117488
Abstract: Abstract The study of ligand interactions with nucleic acid structures such as G-quadruplexes versus double-stranded DNA is important because these interactions are fundamental for many intracellular processes. In the investigation of ligand-DNA binding process, achieving… read more here.
Keywords: towards dna; duplex dna; dna; study ... See more keywords
Mechanism for the binding of netropsin to hairpin DNA revealed using nanoscale ion emitters in native mass spectrometry.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.9b04209
Abstract: Netropsin is one of the first ligands to be discovered that selectively binds to the minor groove of DNA and is actively used as a scaffold for developing potential anticancer and antibiotic agents. The mechanism… read more here.
Keywords: duplex dna; native mass; mechanism; dna ... See more keywords
Unveiling the Interaction of Duplex DNA with Graphene Oxide in the Presence of Two Diverse Binders: A Detailed Photophysical Study
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Physical Chemistry C"
DOI: 10.1021/acs.jpcc.7b10752
Abstract: Coupling of biomolecules with nanomaterials has drawn immense attraction because of the improved synergistic properties, functions, and biocompatible nature. Thus, this process manifests its important role and fascinating potential in various nanobiotechnogical, biomedical, biosensing, and… read more here.
Keywords: graphene oxide; presence; duplex dna; dna ... See more keywords
Stabilisation of half MCM ring by Cdt1 during DNA insertion
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-21932-8
Abstract: Origin licensing ensures precise once per cell cycle replication in eukaryotic cells. The Origin Recognition Complex, Cdc6 and Cdt1 load Mcm2-7 helicase (MCM) into a double hexamer, bound around duplex DNA. The complex formed by… read more here.
Keywords: duplex dna; dna; dna insertion; mcm cdt1 ... See more keywords
Design and synthesis of purine nucleoside analogues for the formation of stable anti-parallel-type triplex DNA with duplex DNA bearing the 5mCG base pair
Sign Up to like & getrecommendations! Published in 2021 at "RSC Advances"
DOI: 10.1039/d1ra02831f
Abstract: Ryotaro Notomi, Lei Wang, Shigeki Sasaki* and Yosuke Taniguchi *a We herein demonstrated for the first time the direct recognition of duplex DNA bearing the 5-methyl-20deoxycytosine and 20-deoxyguanosine base pair by triplex DNA formation. Triplex-forming… read more here.
Keywords: dna; nucleoside analogues; base pair; triplex dna ... See more keywords
SV40 T-antigen uses a DNA shearing mechanism to initiate origin unwinding
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2216240119
Abstract: Significance The initiation of replication of duplex DNA genomes requires that the duplex be opened up for helicase unwinding and to enable assembly of replisome machines that act at DNA replication forks. Cellular and many… read more here.
Keywords: duplex dna; shearing mechanism; dna; dna shearing ... See more keywords
"Helicase" Activity promoted through dynamic interactions between a ssDNA translocase and a diffusing SSB protein.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2216777120
Abstract: Replication protein A (RPA) is a eukaryotic single-stranded (ss) DNA-binding (SSB) protein that is essential for all aspects of genome maintenance. RPA binds ssDNA with high affinity but can also diffuse along ssDNA. By itself,… read more here.
Keywords: duplex dna; ssb protein; dna; activity ... See more keywords