Characterization of 2‐Fluoro‐2’‐deoxyadenosine in Duplex, G‐Quadruplex and i‐Motif
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DOI: 10.1002/cbic.202200222
Abstract: Among various kinds of fluorine‐substituted biomolecules, 2‐fluoroadenine (2FA) and its derivatives have been actively investigated as therapeutic reagents, radio‐sensitizers, and 19F NMR probes. In spite of their excellent properties, DNA containing 2FA has not been… read more here.
Keywords: quadruplex motif; duplex quadruplex; fluoro deoxyadenosine; characterization fluoro ... See more keywords
Visualization of ligand-induced c-MYC duplex–quadruplex transition and direct exploration of the altered c-MYC DNA-protein interactions in cells
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DOI: 10.1093/nar/gkac245
Abstract: Abstract Ligand-Induced duplex-quadruplex transition within the c-MYC promoter region is one of the most studied and advanced ideas for c-MYC regulation. Despite its importance, there is a lack of methods for monitoring such process in… read more here.
Keywords: dna; duplex quadruplex; quadruplex transition; ligand ... See more keywords
DNA Base Excision Repair Intermediates Influence Duplex–Quadruplex Equilibrium
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DOI: 10.3390/molecules28030970
Abstract: Although genomic DNA is predominantly duplex under physiological conditions, particular sequence motifs can favor the formation of alternative secondary structures, including the G-quadruplex. These structures can exist within gene promoters, telomeric DNA, and regions of… read more here.
Keywords: dna; duplex quadruplex; damage; repair intermediates ... See more keywords