Single pembrolizumab treatment causing profound durable response in a patient with pulmonary pleomorphic carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Respiratory Medicine Case Reports"
DOI: 10.1016/j.rmcr.2019.100879
Abstract: We report a case of a 73-year-old man diagnosed with pulmonary pleomorphic carcinoma who showed profound durable response after a single treatment with pembrolizumab. The patient underwent a diagnostic workup in our hospital due to… read more here.
Keywords: pulmonary pleomorphic; durable response; treatment; pleomorphic carcinoma ... See more keywords
Durable response with single-agent acalabrutinib in patients with relapsed or refractory mantle cell lymphoma
Sign Up to like & getrecommendations! Published in 2019 at "Leukemia"
DOI: 10.1038/s41375-019-0575-9
Abstract: Winkelmann N, Aranaz P, et al. Mutations in SETBP1 are recurrent in myelodysplastic syndromes and often coexist with cytogenetic markers associated with disease progression. Br J Haematol. 2013;163:235–9. 9. Nguyen N, Vishwakarma BA, Oakley K,… read more here.
Keywords: export; durable response; nuclear export; crm1 ... See more keywords
Stroma remodeling and reduced cell division define durable response to PD-1 blockade in melanoma
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-14632-2
Abstract: Although immune checkpoint inhibitors (ICIs) have achieved unprecedented results in melanoma, the biological features of the durable responses initiated by these drugs remain unknown. Here we show the genetic and phenotypic changes induced by treatment… read more here.
Keywords: melanoma; stroma remodeling; response; blockade ... See more keywords
Efficacy and safety of eltrombopag in the treatment of Chinese children with chronic immune thrombocytopenia.
Sign Up to like & getrecommendations! Published in 2021 at "Hematology"
DOI: 10.1080/16078454.2020.1856511
Abstract: OBJECTIVES Our aim is to evaluate initial efficacy, safety, and durable response of eltrombopag in the treatment of Chinese children with chronic immune thrombocytopenia (cITP). METHODS This was a retrospective, single-center cohort study including 30… read more here.
Keywords: response; efficacy safety; eltrombopag treatment; durable response ... See more keywords
Predictive biomarkers for PD-1/PD-L1 checkpoint inhibitor response in NSCLC: an analysis of clinical trial and real-world data
Sign Up to like & getrecommendations! Published in 2023 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-006464
Abstract: Background Many biomarkers have been proposed to be predictive of response to anti-programmed cell death protein-1 (PD-1)/anti-programmed death ligand-1 (PD-L1) checkpoint inhibitors (CPI). However, conflicting observations and lack of consensus call for an assessment of… read more here.
Keywords: durable response; world data; cpi; response ... See more keywords
Durable Response to Pazopanib in a Patient with Fumarate Hydratase-Mutant Tubulocystic Renal Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Case Reports in Oncology"
DOI: 10.1159/000528697
Abstract: Abstract Tubulocystic carcinoma of the kidney (TC-RCC) is a rare renal tumor and has been recently included as a distinct entity in WHO classification of renal neoplasms. We report the case of a patient with… read more here.
Keywords: response pazopanib; fumarate hydratase; durable response; carcinoma ... See more keywords
Durable Response to Vemurafenib and Cobimetinib for the Treatment of BRAF-Mutated Metastatic Melanoma in Routine Clinical Practice
Sign Up to like & getrecommendations! Published in 2021 at "OncoTargets and therapy"
DOI: 10.2147/ott.s325208
Abstract: Background The combination of BRAF and MEK inhibitors delays the onset of resistance and provides more sustained and dramatic responses in comparison with a BRAF inhibitor in monotherapy. The objective of the study was to… read more here.
Keywords: treatment; vemurafenib cobimetinib; response; durable response ... See more keywords
A Durable Response after the Discontinuation of Nivolumab in an Advanced Gastric Cancer Patient
Sign Up to like & getrecommendations! Published in 2020 at "Internal Medicine"
DOI: 10.2169/internalmedicine.5893-20
Abstract: A durable response after the discontinuation of immune checkpoint-inhibitor therapy has previously been reported in several cancers. We herein describe a patient with gastric cancer who maintained a durable response after the discontinuation of nivolumab.… read more here.
Keywords: gastric cancer; durable response; response discontinuation; response ... See more keywords
Durable response to bevacizumab in adults with recurrent pilocytic astrocytoma
Sign Up to like & getrecommendations! Published in 2018 at "CNS Oncology"
DOI: 10.2217/cns-2017-0039
Abstract: Background: Adult pilocytic astrocytomas are rare and highly vascular tumors. Aim: We hypothesized that they may be uniquely responsive to bevacizumab (BEV). Patients: We present four adult patients with pathologically diagnosed WHO grade I pilocytic… read more here.
Keywords: bevacizumab; pilocytic astrocytoma; response; durable response ... See more keywords
Durable response to combination radiotherapy and immunotherapy in EP-resistant lung large-cell neuroendocrine carcinoma with B2M and STK11 mutations: a case report.
Sign Up to like & getrecommendations! Published in 2020 at "Immunotherapy"
DOI: 10.2217/imt-2019-0166
Abstract: Lung large-cell neuroendocrine carcinoma (LCNEC) is a rare tumor with poor prognosis. Despite the increasing prevalence of immune checkpoint inhibitors (ICIs) across a broad spectrum of solid tumors, very limited information is available about the… read more here.
Keywords: lung large; cell neuroendocrine; large cell; neuroendocrine carcinoma ... See more keywords