The DedA superfamily member PetA is required for the transbilayer distribution of phosphatidylethanolamine in bacterial membranes.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2301979120
Abstract: The sorting of phospholipids between the inner and outer leaflets of the membrane bilayer is a fundamental problem in all organisms. Despite years of investigation, most of the enzymes that catalyze phospholipid reorientation in bacteria… read more here.
Keywords: duramycin; superfamily member; deda superfamily; peta required ... See more keywords
Substrate-assisted enzymatic formation of lysinoalanine in duramycin.
Sign Up to like & getrecommendations! Published in 2018 at "Nature Chemical Biology"
DOI: 10.2210/pdb6c0g/pdb
Abstract: Duramycin is a heavily post-translationally modified peptide that binds phosphatidylethanolamine. It has been investigated as an antibiotic, an inhibitor of viral entry, a therapeutic for cystic fibrosis, and a tumor and vasculature imaging agent. Duramycin… read more here.
Keywords: substrate assisted; lysinoalanine; substrate; formation ... See more keywords