Downregulation of tripartite motif protein 11 attenuates cardiomyocyte apoptosis after ischemia/reperfusion injury via DUSP1-JNK1/2.
Sign Up to like & getrecommendations! Published in 2021 at "Cell biology international"
DOI: 10.1002/cbin.11716
Abstract: BACKGROUND Currently, the prevention of ischemic diseases such as myocardial infarction associated with ischemia/reperfusion (I/R) injury remains to be a challenge. Thus, this study was designed to explore the effects of tripartite motif protein 11… read more here.
Keywords: overexpression; trim11; apoptosis; dusp1 ... See more keywords
MAPK pathways regulation by DUSP1 in the development of osteosarcoma: Potential markers and therapeutic targets
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22619
Abstract: Osteosarcoma (OS) is the most frequent primary bone tumor that affect children and adolescents. This tumor is highly aggressive with high risk of metastasis and the implementation of new drugs has not been successful. The… read more here.
Keywords: dusp1; therapeutic targets; gene expression; mapk pathways ... See more keywords
MiR-337-3p confers protective effect on facet joint osteoarthritis by targeting SKP2 to inhibit DUSP1 ubiquitination and inactivate MAPK pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Cell biology and toxicology"
DOI: 10.1007/s10565-021-09665-2
Abstract: OBJECTIVE To probe the performance of miR-337-3p on the facet joint osteoarthritis (FJOA) and its underlying mechanism. METHODS qRT-PCR and Western blot were utilized to analyze the levels of miR-337-3p and DUSP1 in the synovial… read more here.
Keywords: mir 337; dusp1; facet joint; joint osteoarthritis ... See more keywords
DUSP1 alleviates cardiac ischemia/reperfusion injury by suppressing the Mff-required mitochondrial fission and Bnip3-related mitophagy via the JNK pathways
Sign Up to like & getrecommendations! Published in 2018 at "Redox Biology"
DOI: 10.1016/j.redox.2017.11.004
Abstract: Mitochondrial fission and selective mitochondrial autophagy (mitophagy) form an essential axis of mitochondrial quality control that plays a critical role in the development of cardiac ischemia-reperfusion (IR) injury. However, the precise upstream molecular mechanism of… read more here.
Keywords: jnk; dusp1; fission; mff ... See more keywords
Nr1d1 inhibition mitigates intermittent hypoxia-induced pulmonary hypertension via Dusp1-mediated Erk1/2 deactivation and mitochondrial fission attenuation
Sign Up to like & getrecommendations! Published in 2024 at "Cell Death Discovery"
DOI: 10.1038/s41420-024-02219-5
Abstract: Intermittent hypoxia (IH) precipitates pulmonary vasoconstriction, culminating in the onset of pulmonary hypertension (PH) among individuals afflicted with sleep apnea. While Nuclear receptor subfamily 1 group D member 1 (Nr1d1) is progressively recognized as pivotal… read more here.
Keywords: dusp1; fission; pulmonary hypertension; nr1d1 ... See more keywords
DUSP1 and SOX2 expression determine squamous cell carcinoma of the salivary gland progression
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-65945-x
Abstract: Salivary gland squamous cell carcinomas (SG-SCCs) constitute a rare type of head and neck cancer which is linked to poor prognosis. Due to their low frequency, the molecular mechanisms responsible for their aggressiveness are poorly… read more here.
Keywords: dusp1; progression; sox2; squamous cell ... See more keywords
Dusp1 modulates activin/smad2 mediated germ layer specification via FGF signal inhibition in Xenopus embryos
Sign Up to like & getrecommendations! Published in 2020 at "Animal Cells and Systems"
DOI: 10.1080/19768354.2020.1847732
Abstract: ABSTRACT Activin, a member of the transforming growth factor (TGF-β) superfamily, induces mesoderm, endoderm and neuro-ectoderm formation in Xenopus embryos. Despite several previous studies, the complicated gene regulatory network and genes involved in this induction… read more here.
Keywords: dusp1; xenopus embryos; activin smad2; expression ... See more keywords
Abstract We0043: DUSP1-dependent regulation of the mTOR/TFEB axis as a common dysregulated signaling pathway in obesity as well as LDL-induced NK cell dysfunction
Sign Up to like & getrecommendations! Published in 2025 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atv.45.suppl_1.we0043
Abstract: Background: Obesity and hyperlipidemia disproportionally affect African American (AA) women due to lifelong exposure to adverse social determinants of health (aSDoH), leading to greater cardiovascular disease (CVD) risk. In a previous study we identified Dual… read more here.
Keywords: dusp1; tfeb; obesity; mtor tfeb ... See more keywords
Obesity modulates NK cell activity via LDL and DUSP1 signaling for populations with adverse social determinants
Sign Up to like & getrecommendations! Published in 2024 at "JCI Insight"
DOI: 10.1172/jci.insight.180606
Abstract: African American (AA) women are disproportionately affected by obesity and hyperlipidemia, particularly in the setting of adverse social determinants of health (aSDoH) that contribute to health disparities. Obesity, hyperlipidemia, and aSDoH appear to impair NK… read more here.
Keywords: dusp1; obesity; cell; social determinants ... See more keywords
DUSP1 inhibits cell proliferation, metastasis and invasion and angiogenesis in gallbladder cancer
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.14815
Abstract: DUSP1/MKP1 is a dual-specific phosphatase that regulates MAPK activity and is known to play a key role in tumor biology. Its function in gallbladder cancer (GBC) remains largely unknown, however. By exploring its activities in… read more here.
Keywords: metastasis; cell proliferation; gallbladder cancer; dusp1 ... See more keywords
MiR-200c-3p Regulates DUSP1/MAPK Pathway in the Nonalcoholic Fatty Liver After Laparoscopic Sleeve Gastrectomy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.792439
Abstract: Aim Non-alcoholic fatty liver disease (NAFLD) is a health burden worldwide, which is closely related to obesity. The effect of sleeve gastrectomy (SG) on NAFLD is efficient, and the underlying mechanism remains unknown. Our study… read more here.
Keywords: dusp1; expression; sleeve gastrectomy; mir 200c ... See more keywords