Human miRNA miR-675 inhibits DUX4 expression and may be exploited as a potential treatment for Facioscapulohumeral muscular dystrophy.
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DOI: 10.1038/s41467-021-27430-1
Abstract: Facioscapulohumeral muscular dystrophy (FSHD) is a potentially devastating myopathy caused by de-repression of the DUX4 gene in skeletal muscles. Effective therapies will likely involve DUX4 inhibition. RNA interference (RNAi) is one powerful approach to inhibit… read more here.
Keywords: muscular dystrophy; inhibits dux4; dux4 expression; mir 675 ... See more keywords