NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins
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DOI: 10.7554/elife.31023
Abstract: The DUX4 transcription factor is encoded by a retrogene embedded in each unit of the D4Z4 macrosatellite repeat. DUX4 is normally expressed in the cleavage-stage embryo, whereas chromatin repression prevents DUX4 expression in most somatic… read more here.
Keywords: dux4; repression; mbd3l proteins; nurd caf ... See more keywords