ASPM promotes hepatocellular carcinoma progression by activating Wnt/β‐catenin signaling through antagonizing autophagy‐mediated Dvl2 degradation
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DOI: 10.1002/2211-5463.13278
Abstract: Hepatocellular carcinoma (HCC) is one of the most fatal cancers worldwide. In this article, we show that expression of abnormal spindle‐like microcephaly‐associated protein (ASPM) is up‐regulated in liver cancer samples, and this up‐regulation is significantly… read more here.
Keywords: hepatocellular carcinoma; catenin signaling; autophagy mediated; dvl2 ... See more keywords
Reversible acetylation modulates dishevelled-2 puncta formation in canonical Wnt signaling activation
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DOI: 10.1038/s41392-020-00229-0
Abstract: Dear Editor, Dishevelled-2 (DVL2) is a central adaptor protein that propagates signals from upstream receptors to downstream effector β-catenin in canonical Wnt signaling. At high local concentration, DVL2 assembles into signalosomes through DIX domain-mediated homo-polymerization… read more here.
Keywords: acetylation; puncta; supplementary fig; formation ... See more keywords
Ubiquitin assisted phase separation of Dishevelled-2 promotes Wnt signaling.
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DOI: 10.1242/jcs.260284
Abstract: Dishvelled-2 (Dvl2) is an essential component of Wnt pathway, which controls several cell fate decisions during development such as proliferation, survival and differentiation. Dvl2 forms higher-order protein assemblies in cell that are critical for relaying… read more here.
Keywords: phase separation; ubiquitin assisted; dvl2; wnt signaling ... See more keywords
Aberrant expression of SFRP1, SFRP3, DVL2 and DVL3 Wnt signaling pathway components in diffuse gastric carcinoma
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DOI: 10.3892/ol.2021.13083
Abstract: Diffuse gastric carcinoma (DGC) is characterized by poorly cohesive cells, highly invasive growth patterns, poor prognosis and resistance to the majority of available systemic therapeutic strategies. It has been previously reported that the Wnt/β-catenin signaling… read more here.
Keywords: sfrp3; dvl3; dgc; dvl2 ... See more keywords