The effect of dextromethorphan use in Parkinson's disease: A 6-hydroxydopamine rat model and population-based study.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.172639
Abstract: This study investigated the effect of dextromethorphan (DXM) against Parkinson's disease (PD) in rats and explored the association between DXM dose and PD risk in elderly patients 65 years and older using a population-based database.… read more here.
Keywords: effect dextromethorphan; population based; study; effect ... See more keywords
Photocatalytic degradation and mineralization of dexamethasone using WO3 and ZrO2 nanoparticles: Optimization of operational parameters and kinetic studies
Sign Up to like & getrecommendations! Published in 2019 at "Journal of water process engineering"
DOI: 10.1016/j.jwpe.2019.100969
Abstract: Abstract Pharmaceutical compounds are one the main pollutant of the environment. In the present study, photocatalytic processes using zirconium dioxide (ZrO2) and tungsten trioxide (WO3) nanoparticles have been investigated for the feasibility of dexamethasone (DXM)… read more here.
Keywords: mineralization; dxm; wo3 zro2; dexamethasone ... See more keywords
Dextromethorphan upregulates osteoblast and osteoclast activity but does not attenuate ovariectomy‐induced osteoporosis
Sign Up to like & getrecommendations! Published in 2017 at "Life Sciences"
DOI: 10.1016/j.lfs.2017.01.011
Abstract: Aims: Study on the in vivo regulatory role of glutamate in osteoblast (OB) and osteoclast (OC) differentiation is less advanced. The present study investigated the effect of dextromethorphan (DXM), an N‐methyl‐D‐aspartate receptors (NMDARs) antagonist, on… read more here.
Keywords: bone; osteoblast osteoclast; upregulates osteoblast; dxm ... See more keywords
LC-MS/MS analyses of bile and histological analyses of thymus as diagnostic tools to detect low dose dexamethasone illicit treatment in beef cattle at slaughterhouse
Sign Up to like & getrecommendations! Published in 2020 at "Steroids"
DOI: 10.1016/j.steroids.2020.108671
Abstract: Dexamethasone (DXM) is a synthetic adrenal corticosteroid with anti-inflammatory properties used for therapeutic purposes in a wide range of pathologies and of the most common corticosteroids used for anabolic purposes in beef cattle. It is… read more here.
Keywords: treatment; beef cattle; analyses bile; dxm ... See more keywords
Pharmacokinetics and pharmacodynamics of dextromethorphan: clinical and forensic aspects
Sign Up to like & getrecommendations! Published in 2020 at "Drug Metabolism Reviews"
DOI: 10.1080/03602532.2020.1758712
Abstract: Abstract Dextromethorphan (DXM) is a safe and effective antitussive agent present in several over the counter cough and cold medications. At higher doses, it causes psychoactive effects, making it appealing for abuse. In this work,… read more here.
Keywords: clinical forensic; forensic aspects; pharmacodynamics dextromethorphan; pharmacokinetics pharmacodynamics ... See more keywords
Combination of ATRA and High-Dose Dexamethasone As First-Line Treatment in Adult Immune Thrombocytopenia:a Randomized, Phase 2, Open-Label Trial
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-125242
Abstract: Introductions Immune thrombocytopenia (ITP) is an acquired thrombocytopenia caused by immune-mediated platelet destruction and impaired platelet production. As the immunosuppressive therapy, high-dose dexamethasone (HD-DXM) has been recommended as the standard first-line treatment. Nevertheless, approximately half… read more here.
Keywords: response; first line; treatment; dxm ... See more keywords
Dexamethasone therapy versus surgery for chronic subdural haematoma (DECSA trial): study protocol for a randomised controlled trial
Sign Up to like & getrecommendations! Published in 2018 at "Trials"
DOI: 10.1186/s13063-018-2945-4
Abstract: BackgroundChronic subdural haematoma (CSDH) is a common neurological disease with a rapidly rising incidence due to increasing age and widespread use of anticoagulants. Surgical intervention by burr-hole craniotomy (BHC) is the current standard practice for… read more here.
Keywords: randomised controlled; trial; study; haematoma ... See more keywords
Low-Dose Dextromethorphan for the Treatment of Fibromyalgia Pain: Results from a Longitudinal, Single-Blind, Placebo-Controlled Pilot Trial
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Pain Research"
DOI: 10.2147/jpr.s285609
Abstract: Objective Fibromyalgia (FM) is a debilitating chronic pain condition with few treatment options. Central sensitization and neuroinflammation have been forwarded as models of FM pathophysiology, both of which indicate dextromethorphan (DXM) as a potential treatment.… read more here.
Keywords: single blind; pain; treatment; dxm ... See more keywords
Impact of immunosuppressive regimen on ICU acquired pneumonia in critically ill COVID-19.
Sign Up to like & getrecommendations! Published in 2023 at "Minerva anestesiologica"
DOI: 10.23736/s0375-9393.23.17196-3
Abstract: BACKGROUND Immunosuppressors (IS) such as Dexamethasone (DXM), Tocilizumab, and high-dose methylprednisolone boli (HDMB), are used in COVID-19-related acute respiratory distress syndrome (ARDS). This study aimed to determine whether COVID-19 ARDS-related combined IS therapy was associated… read more here.
Keywords: dxm; hdmb; icu acquired; iap ... See more keywords
Dexamethasone Inhibits S. aureus-Induced Neutrophil Extracellular Pathogen-Killing Mechanism, Possibly through Toll-Like Receptor Regulation
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2017.00060
Abstract: Neutrophils release neutrophil extracellular traps (NETs) in a pathogen-killing process called NETosis. Excessive NETs formation, however, is implicated in disease pathogenesis. Therefore, to understand how NETosis is regulated, we examined the effect of dexamethasone (DXM),… read more here.
Keywords: neutrophil extracellular; netosis; nets formation; aureus induced ... See more keywords
Atorvastatin combined with low-dose dexamethasone improves the neuroinflammation and survival in mice with intracerebral hemorrhage
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.967297
Abstract: Intracerebral hemorrhage (ICH) is a fatal disease with high mortality and poor prognosis that triggers multiple severe brain injuries associated with an inflammatory cascade response that cannot be treated with any effective medication. Atorvastatin (ATO)… read more here.
Keywords: dxm; mice; combined low; intracerebral hemorrhage ... See more keywords