Antibacterial Target DXP Synthase Catalyzes the Cleavage of d-Xylulose 5-Phosphate: a Study of Ketose Phosphate Binding and Ketol Transfer Reaction.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00274
Abstract: The bacterial enzyme 1-deoxy-d-xylulose 5-phosphate synthase (DXPS) catalyzes the formation of DXP from pyruvate and d-glyceraldehyde 3-phosphate (d-GAP) in a thiamin diphosphate (ThDP)-dependent manner. In addition to its role in isoprenoid biosynthesis, DXP is required… read more here.
Keywords: phosphate; synthase; dxps; donor ... See more keywords
Potent Inhibition of E. coli DXP Synthase by a gem-Diaryl Bisubstrate Analog
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DOI: 10.1021/acsinfecdis.3c00734
Abstract: New antimicrobial strategies are needed to address pathogen resistance to currently used antibiotics. Bacterial central metabolism is a promising target space for the development of agents that selectively target bacterial pathogens. 1-Deoxy-d-xylulose 5-phosphate synthase (DXPS)… read more here.
Keywords: synthase; dxps; inhibition; bisubstrate analog ... See more keywords
DXP Synthase Function in a Bacterial Metabolic Adaptation and Implications for Antibacterial Strategies
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DOI: 10.3390/antibiotics12040692
Abstract: Pathogenic bacteria possess a remarkable ability to adapt to fluctuating host environments and cause infection. Disturbing bacterial central metabolism through inhibition of 1-deoxy-d-xylulose 5-phosphate synthase (DXPS) has the potential to hinder bacterial adaptation, representing a… read more here.
Keywords: function; adaptation; metabolic adaptation; antibacterial strategies ... See more keywords