Progestogens and PGRMC1-dependent breast cancer tumor growth: An in-vitro and xenograft study.
Sign Up to like & getrecommendations! Published in 2019 at "Maturitas"
DOI: 10.1016/j.maturitas.2019.01.015
Abstract: OBJECTIVES A few observational studies have suggested that progesterone and dydrogesterone may have a lower risk of breast cancer than other progestogens. In our earlier xenograft animal experiments, progesterone did not stimulate breast tumors. The… read more here.
Keywords: progesterone; study; tumor growth; dydrogesterone ... See more keywords
PGRMC1 in animal breast cancer tissue and blood is associated with increased tumor growth with norethisterone in contrast to progesterone and dydrogesterone: four-arm randomized placebo-controlled xenograft study
Sign Up to like & getrecommendations! Published in 2020 at "Gynecological Endocrinology"
DOI: 10.1080/09513590.2020.1742689
Abstract: Abstract Progesterone receptor membrane component 1 (PGRMC1) is mediating strong breast cancer cell proliferation induced by certain synthetic progestogens which we have shown within already published in vitro studies. Aim was now to use an… read more here.
Keywords: pgrmc1; dydrogesterone; blood; growth ... See more keywords
A prospective, open-label, single-arm study to evaluate the efficacy of dydrogesterone in the treatment of endometrial polyps
Sign Up to like & getrecommendations! Published in 2020 at "Gynecological Endocrinology"
DOI: 10.1080/09513590.2020.1840546
Abstract: Abstract Object To evaluate the efficacy of dydrogesterone for the treatment of premenopausal patients with endometrial polyps (EPs). Methods A single-center, open-label, prospective, single-arm clinical treatment trial was conducted in patients of reproductive age with… read more here.
Keywords: efficacy dydrogesterone; dydrogesterone treatment; dydrogesterone; efficacy ... See more keywords
Dydrogesterone after 60 years: a glance at the safety profile
Sign Up to like & getrecommendations! Published in 2021 at "Gynecological Endocrinology"
DOI: 10.1080/09513590.2021.2016692
Abstract: Abstract Objective To provide an evidence-based safety and tolerability overview of dydrogesterone under various progesterone-deficient conditions as a commemoration of its role in managing women’s reproductive health over the past 60 years. Methods To identify relevant… read more here.
Keywords: safety; risk; years glance; dydrogesterone ... See more keywords
Dydrogesterone as an oral alternative to vaginal progesterone for IVF luteal phase support: A systematic review and individual participant data meta-analysis
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0241044
Abstract: The aim of this systematic review and meta-analysis was to conduct a comprehensive assessment of the evidence on the efficacy and safety of oral dydrogesterone versus micronized vaginal progesterone (MVP) for luteal phase support. Embase… read more here.
Keywords: phase support; analysis; dydrogesterone; luteal phase ... See more keywords