Microenvironment-driven dynamic chromatin changes in glioblastoma recapitulate early neural development at single-cell resolution.
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DOI: 10.1158/0008-5472.can-22-2872
Abstract: The tumor microenvironment is necessary for recapitulating the intratumoral heterogeneity and cell state plasticity found in human primary glioblastoma (GBM). Conventional models do not accurately recapitulate the spectrum of GBM cellular states, hindering elucidation of… read more here.
Keywords: neural development; cell; dynamic chromatin; microenvironment ... See more keywords