Dynamic duo – FMRP and TDP-43: Regulating common targets, causing different diseases
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research"
DOI: 10.1016/j.brainres.2018.04.034
Abstract: RNA binding proteins play essential roles during development and aging, and are also involved in disease pathomechanisms. RNA sequencing and omics analyses have provided a window into systems level alterations in neurological disease, and have… read more here.
Keywords: common targets; regulating common; fmrp tdp; tdp regulating ... See more keywords
Dangerous dynamic duo: Lactic acid and PD-1 blockade.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer cell"
DOI: 10.1016/j.ccell.2022.01.008
Abstract: In this issue of Cancer Cell, Kumagai et al. reveal lactic acid as a mediator of checkpoint blockade resistance. Tumor-derived lactic acid promotes T regulatory cell (Treg) activity and impairs CD8+ T cell function. PD-1 blockade synergizes… read more here.
Keywords: lactic acid; dangerous dynamic; acid blockade; acid ... See more keywords