Optimizing performance of semi‐continuous cell culture in an ambr15™ microbioreactor using dynamic flux balance modeling
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology Progress"
DOI: 10.1002/btpr.2585
Abstract: The ambr bioreactors are single‐use microbioreactors for cell line development and process optimization. With operating conditions for large‐scale biopharmaceutical production properly scaled down, microbioreactors such as the ambr15™ can potentially be used to predict the… read more here.
Keywords: flux balance; production; process; dynamic flux ... See more keywords
A systematic approach for finding the objective function and active constraints for dynamic flux balance analysis
Sign Up to like & getrecommendations! Published in 2018 at "Bioprocess and Biosystems Engineering"
DOI: 10.1007/s00449-018-1899-y
Abstract: Dynamic flux balance analysis (DFBA) has become an instrumental modeling tool for describing the dynamic behavior of bioprocesses. DFBA involves the maximization of a biologically meaningful objective subject to kinetic constraints on the rate of… read more here.
Keywords: flux balance; objective function; balance analysis; approach finding ... See more keywords