Steric‐Adaptive Biocatalysis: Imine Reductase‐Mediated Dynamic Kinetic Resolution for Atroposelective Synthesis of Hindered Biaryl Amines
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202510455
Abstract: As an efficient and environmentally benign strategy, enzymatic catalysis has emerged with high reactivity and selectivity for atropisomeric structures. Atropisomeric biaryl amines are of great importance in drug development and asymmetric catalysis. However, substrates with… read more here.
Keywords: imine reductase; dynamic kinetic; biaryl amines; atropisomeric biaryl ... See more keywords
Dynamic Kinetic Resolution of 2‐Hydroxybiaryl Atropisomers via Lipase‐Catalyzed Enantioselective O‐Acylation
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DOI: 10.1002/cctc.202400932
Abstract: The increasing interest in axially chiral biaryl moieties, which are prevalent in chiral ligands, organocatalysts, and bioactive molecules, has raised the need for developing novel efficient synthetic methods for these types of molecules. In addition… read more here.
Keywords: dynamic kinetic; enantioselective acylation; lipase catalyzed; resolution ... See more keywords
Bioreductive dynamic kinetic resolution of ethyl 2-methoxy-3-oxo-3-phenylpropanoate
Sign Up to like & getrecommendations! Published in 2020 at "Catalysis Communications"
DOI: 10.1016/j.catcom.2019.105865
Abstract: Abstract Ketoreductase ChKRED12 from Chryseobacterium sp. CA49 was identified as a highly stereoselective catalyst for the bioreductive production of (2S,3S)-ethyl 3-hydroxy-2-methoxy-3-phenylpropanoate (EMHP) through dynamic kinetic resolution. Its performance was further improved using semi-rational design strategies… read more here.
Keywords: bioreductive dynamic; ethyl; kinetic resolution; methoxy ... See more keywords
Dynamic kinetic resolution of amines by using palladium nanoparticles confined inside the cages of amine-modified MIL-101 and lipase
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Catalysis"
DOI: 10.1016/j.jcat.2018.04.006
Abstract: Abstract Dynamic kinetic resolution (DKR) of amines is an important strategy for the synthesis of chiral drugs and their building blocks; however, improving the matchability of metal-catalyzed racemization and enzymatic resolution is still a task.… read more here.
Keywords: resolution; inside cages; kinetic resolution; dynamic kinetic ... See more keywords
A substitution/dynamic kinetic resolution – Asymmetric transfer hydrogenation tandem process for preparation of stereocenters β-hydroxy sulfones
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Catalysis"
DOI: 10.1016/j.mcat.2018.04.019
Abstract: Abstract A noval method for the synthesis of optically active β-hydroxy sulfones was developed. Through a substitution/dynamic kinetic resolution–asymmetric transfer hydrogenation, the presented method was based on one-pot enantioselective organic transformations of α–bromoindenones and sodium… read more here.
Keywords: resolution asymmetric; hydroxy sulfones; kinetic resolution; dynamic kinetic ... See more keywords
Dynamic kinetic resolution of 1-substituted-3-methyl-3-phospholene oxides via the formation of diastereomeric alkoxyphospholenium salts
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron"
DOI: 10.1016/j.tet.2018.07.058
Abstract: Abstract A dynamic kinetic resolution method based on the formation of covalent diastereomeric intermediates was elaborated for the preparation of enantiomerically enriched 1-substituted-3-methyl-3-phospholene oxides. The 3-phospholene oxides were first converted to the corresponding chloro-3-phospholenium chlorides.… read more here.
Keywords: phospholene oxides; resolution; kinetic resolution; dynamic kinetic ... See more keywords
A highly diastereoselective chloride-mediated dynamic kinetic resolution at phosphorus on-route to a key intermediate in the synthesis of GSK2248761A
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2018.04.018
Abstract: Abstract A highly diastereoselective chloride-mediated dynamic kinetic resolution at phosphorus has been developed to access a key intermediate in the synthesis of GSK2248761A. This procedure utilises a soluble chloride source and a cheap readily available… read more here.
Keywords: chloride mediated; diastereoselective chloride; dynamic kinetic; mediated dynamic ... See more keywords
Advances in Stereoconvergent Catalysis from 2005 to 2015: Transition-Metal-Mediated Stereoablative Reactions, Dynamic Kinetic Resolutions, and Dynamic Kinetic Asymmetric Transformations.
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DOI: 10.1021/acs.chemrev.6b00731
Abstract: Stereoconvergent catalysis is an important subset of asymmetric synthesis that encompasses stereoablative transformations, dynamic kinetic resolutions, and dynamic kinetic asymmetric transformations. Initially, only enzymes were known to catalyze dynamic kinetic processes, but recently various synthetic… read more here.
Keywords: asymmetric transformations; resolutions dynamic; stereoconvergent catalysis; kinetic asymmetric ... See more keywords
Feedback Inhibition in Chemical Catalysis Leads the Dynamic Kinetic to Kinetic Resolution in C3-Indolylation of Spiro-epoxyoxindoles.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c00028
Abstract: The first feedback inhibition, similar to enzyme catalysis, in the Co(III)salen-catalyzed asymmetric ring-opening reaction of N-free spiro-epoxyoxyindole has been discovered, which leads dynamic kinetic to kinetic resolution. This is the first report of the enantioselective… read more here.
Keywords: kinetic kinetic; kinetic resolution; dynamic kinetic; leads dynamic ... See more keywords
Organocatalytic Atroposelective Synthesis of Isoquinolines via Dynamic Kinetic Resolution.
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DOI: 10.1021/acs.orglett.1c04330
Abstract: Herein, a highly enantioselective Pictet-Spengler reaction for the synthesis of axially chiral tetrahydroisoquinolines via dynamic kinetic resolution is described. Chiral phosphoric acids catalyze cyclization to yield single regioisomeric isoquinolines with excellent enantioselectivities around the C-C… read more here.
Keywords: via dynamic; organocatalytic atroposelective; synthesis; dynamic kinetic ... See more keywords
Pd-Catalyzed Dynamic Kinetic Asymmetric Cross-Coupling of Heterobiaryl Bromides with N-Tosylhydrazones
Sign Up to like & getrecommendations! Published in 2022 at "Organic Letters"
DOI: 10.1021/acs.orglett.2c01355
Abstract: A dynamic kinetic asymmetric Pd-catalyzed cross-coupling reaction of heterobiaryl bromides with ketone N-tosylhydrazones for the synthesis of heterobiaryl styrenes is described. The combination of Pd(dba)2 as a precatalyst with a TADDOL-derived phosphoramidite ligand provides the… read more here.
Keywords: dynamic kinetic; heterobiaryl bromides; kinetic asymmetric; cross coupling ... See more keywords