Finite sample variance estimation for optimal dynamic treatment regimes of survival outcomes.
Sign Up to like & getrecommendations! Published in 2020 at "Statistics in medicine"
DOI: 10.1002/sim.8735
Abstract: Deriving valid confidence intervals for complex estimators is a challenging task in practice. Estimators of dynamic weighted survival modeling (DWSurv), a method to estimate an optimal dynamic treatment regime of censored outcomes, are asymptotically normal… read more here.
Keywords: asymptotic variance; estimation; dynamic treatment; optimal dynamic ... See more keywords
Bayesian set of best dynamic treatment regimes: Construction and sample size calculation for SMARTs with binary outcomes
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DOI: 10.1002/sim.9323
Abstract: Sequential, multiple assignment, randomized trials (SMARTs) compare sequences of treatment decision rules called dynamic treatment regimes (DTRs). In particular, the Adaptive Treatment for Alcohol and Cocaine Dependence (ENGAGE) SMART aimed to determine the best DTRs… read more here.
Keywords: set best; treatment regimes; sample size; dynamic treatment ... See more keywords
Using dynamic treatment regimes to understand erythropoietin-stimulating agent hyporesponsiveness
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DOI: 10.1007/s00467-018-3948-9
Abstract: BackgroundErythropoietin-stimulating agent hyporesponsiveness (ESAH) is associated with increased cardiovascular mortality in patients with end-stage renal disease (ESRD) on hemodialysis. Dynamic treatment regimes (DTR), a clinical decision support (CDS) tool that guides the prescription of specific… read more here.
Keywords: treatment regimes; dynamic treatment; treatment; stimulating agent ... See more keywords
Nonparametric identification and estimation of dynamic treatment effects for survival data in a regression discontinuity design
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DOI: 10.1016/j.econlet.2019.108665
Abstract: Treatment assignment in the survival literature is often assumed to be allocated simultaneously and independently of prospective treatment gains. This paper relaxes these restrictions by introducing dynamic treatment assignment for survival data in a regression… read more here.
Keywords: dynamic treatment; treatment; data regression; survival data ... See more keywords
Interactive Q-Learning for Quantiles
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DOI: 10.1080/01621459.2016.1155993
Abstract: ABSTRACT A dynamic treatment regime is a sequence of decision rules, each of which recommends treatment based on features of patient medical history such as past treatments and outcomes. Existing methods for estimating optimal dynamic… read more here.
Keywords: response; dynamic treatment; interactive learning; learning quantiles ... See more keywords
Semiparametric Bayesian inference for optimal dynamic treatment regimes via dynamic marginal structural models.
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DOI: 10.1093/biostatistics/kxac007
Abstract: Considerable statistical work done on dynamic treatment regimes (DTRs) is in the frequentist paradigm, but Bayesian methods may have much to offer in this setting as they allow for the appropriate representation and propagation of… read more here.
Keywords: treatment regimes; dynamic treatment; bayesian inference; structural models ... See more keywords
Learning and Assessing Optimal Dynamic Treatment Regimes Through Cooperative Imitation Learning
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DOI: 10.1109/access.2022.3193494
Abstract: Dynamic Treatment Regimes (DTRs) are sets of sequential decision rules that can be adapted over time to treat patients with a specific pathology. DTR consists of alternative treatment paths and any of these treatments can… read more here.
Keywords: treatment regimes; dynamic treatment; imitation learning; treatment ... See more keywords
Imputation-based Q-learning for optimizing dynamic treatment regimes with right-censored survival outcome.
Sign Up to like & getrecommendations! Published in 2023 at "Biometrics"
DOI: 10.1111/biom.13872
Abstract: Q-learning has been one of the most commonly used methods for optimizing dynamic treatment regimes (DTRs) in multi-stage decision making. Right-censored survival outcome poses a significant challenge to Q-Learning due to its reliance on parametric… read more here.
Keywords: right censored; treatment regimes; dynamic treatment; imputation ... See more keywords
Estimating individualized treatment rules in longitudinal studies with covariate-driven observation times.
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DOI: 10.1177/09622802231158733
Abstract: The sequential treatment decisions made by physicians to treat chronic diseases are formalized in the statistical literature as dynamic treatment regimes. To date, methods for dynamic treatment regimes have been developed under the assumption that… read more here.
Keywords: individualized treatment; observation times; dynamic treatment; treatment rules ... See more keywords
Dynamic Treatment Regimen Estimation via Regression-Based Techniques: Introducing R Package DTRreg
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DOI: 10.18637/jss.v080.i02
Abstract: Personalized medicine, whereby treatments are tailored to a specific patient rather than a general disease or condition, is an area of growing interest in the fields of biostatistics, epidemiology, and beyond. Dynamic treatment regimens (DTRs)… read more here.
Keywords: package dtrreg; treatment; regression based; dynamic treatment ... See more keywords