Tunable microsecond dynamics of an allosteric switch regulate the activity of a AAA+ disaggregation machine
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09474-6
Abstract: Large protein machines are tightly regulated through allosteric communication channels. Here we demonstrate the involvement of ultrafast conformational dynamics in allosteric regulation of ClpB, a hexameric AAA+ machine that rescues aggregated proteins. Each subunit of ClpB… read more here.
Keywords: machine; tunable microsecond; clpb; dynamics allosteric ... See more keywords
Dynamics of allosteric regulation of the phospholipase C-γ isozymes upon recruitment to membranes
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DOI: 10.1101/2022.02.23.481568
Abstract: Numerous receptor tyrosine kinases and immune receptors activate phospholipase C-gamma (PLC-γ) isozymes at membranes to control diverse cellular processes including phagocytosis, migration, proliferation, and differentiation. The molecular details of this process are not well understood.… read more here.
Keywords: allosteric regulation; plc; regulation phospholipase; dynamics allosteric ... See more keywords
Conformational dynamics and allosteric modulation of the SARS-CoV-2 spike
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.75433
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects cells through binding to angiotensin-converting enzyme 2 (ACE2). This interaction is mediated by the receptor-binding domain (RBD) of the viral spike (S) glycoprotein. Structural and dynamic data… read more here.
Keywords: conformational dynamics; dynamics allosteric; ace2 binding; allosteric modulation ... See more keywords