Conformational Dynamics and Allostery in E2:E3 Interactions Drive Ubiquitination: gp78 and Ube2g2.
Sign Up to like & getrecommendations! Published in 2017 at "Structure"
DOI: 10.1016/j.str.2017.03.016
Abstract: Conformational dynamics plays a fundamental role in molecular recognition and activity in enzymes. The ubiquitin-conjugating enzyme (E2) Ube2g2 functions with the ubiquitin ligase (E3) gp78 to assemble poly-ubiquitin chains on target substrates. Two domains in… read more here.
Keywords: conformational dynamics; interactions drive; allostery interactions; dynamics allostery ... See more keywords
A Major Disease-Related Point Mutation in Spastin Dramatically Alters the Dynamics and Allostery of the Motor.
Sign Up to like & getrecommendations! Published in 2025 at "Biochemistry"
DOI: 10.1021/acs.biochem.4c00693
Abstract: Spastin is a microtubule-severing AAA+ ATPase that is highly expressed in neuronal cells and plays a crucial role in axonal growth, branching, and regeneration. This machine oligomerizes into hexamers in the presence of ATP and… read more here.
Keywords: dynamics allostery; major disease; mutation; spastin ... See more keywords
Hierarchical dynamics in allostery following ATP hydrolysis monitored by single molecule FRET measurements and MD simulationsâ€
Sign Up to like & getrecommendations! Published in 2021 at "Chemical Science"
DOI: 10.1039/d0sc06134d
Abstract: We report on a study that combines advanced fluorescence methods with molecular dynamics (MD) simulations to cover timescales from nanoseconds to milliseconds for a large protein. This allows us to delineate how ATP hydrolysis in… read more here.
Keywords: protein; hierarchical dynamics; atp hydrolysis; allostery following ... See more keywords