The Machado–Joseph disease‐associated form of ataxin‐3 impacts dynamics of clathrin‐coated pits
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DOI: 10.1002/cbin.11312
Abstract: Expansion above a certain threshold in the polyglutamine (polyQ) tract of ataxin‐3 is the main cause of neurodegeneration in Machado–Joseph disease. Ataxin‐3 contains an N‐terminal catalytic domain, called Josephin domain, and a highly aggregation‐prone C‐terminal… read more here.
Keywords: impacts dynamics; ataxin; machado joseph; dynamics clathrin ... See more keywords