Differential dynamics and direct interaction of bound ligands with lipids in multidrug transporter ABCG2.
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DOI: 10.1073/pnas.2213437120
Abstract: ABCG2 is an ATP-binding cassette (ABC) transporter that extrudes a wide range of xenobiotics and drugs from the cell and contributes to multidrug resistance in cancer cells. Following our recent structural characterization of topotecan-bound ABCG2,… read more here.
Keywords: differential dynamics; transporter; dynamics direct; direct interaction ... See more keywords