Plocabulin, a novel tubulin-binding agent, inhibits angiogenesis by modulation of microtubule dynamics in endothelial cells
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DOI: 10.1186/s12885-018-4086-2
Abstract: BackgroundVascular supply of tumors is one of the main targets for cancer therapy. Here, we investigated if plocabulin (PM060184), a novel marine-derived microtubule-binding agent, presents antiangiogenic and vascular-disrupting activities.MethodsThe effects of plocabulin on microtubule network… read more here.
Keywords: microtubule; plocabulin novel; dynamics endothelial; microtubule dynamics ... See more keywords
Dynamics of Endothelial Engagement and Filopodia Formation in Complex 3D Microscaffolds
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DOI: 10.3390/ijms23052415
Abstract: The understanding of endothelium–extracellular matrix interactions during the initiation of new blood vessels is of great medical importance; however, the mechanobiological principles governing endothelial protrusive behaviours in 3D microtopographies remain imperfectly understood. In blood capillaries… read more here.
Keywords: filopodia formation; engagement filopodia; filopodia; endothelial engagement ... See more keywords