Active Site Gate Dynamics Modulate the Catalytic Activity of the Ubiquitination Enzyme E2-25K
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-25476-8
Abstract: The ubiquitin proteasome system (UPS) signals for degradation of proteins through attachment of K48-linked polyubiquitin chains, or alterations in protein-protein recognition through attachment of K63-linked chains. Target proteins are ubiquitinated in three sequential chemical steps… read more here.
Keywords: site gate; dynamics modulate; active site; site ... See more keywords
Exploiting conformational dynamics to modulate the function of designed proteins.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2303149120
Abstract: With the recent success in calculating protein structures from amino acid sequences using artificial intelligence-based algorithms, an important next step is to decipher how dynamics is encoded by the primary protein sequence so as to… read more here.
Keywords: function designed; function; dynamics modulate; conformational dynamics ... See more keywords
It's About Time—Breathing Dynamics Modulate Emotion and Cognition
Sign Up to like & getrecommendations! Published in 2025 at "Psychophysiology"
DOI: 10.1111/psyp.70149
Abstract: The breathing rate, phase, and amplitude have been shown to track changes in emotional states such as anxiety and cognitive performance in tasks that involve perception, attention, and short‐term memory. It is common practice to… read more here.
Keywords: time breathing; time; dynamics modulate; breathing rate ... See more keywords