Remodeling the conformational dynamics of I-motif DNA by helicases in ATP-independent mode at acidic environment
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DOI: 10.1016/j.isci.2021.103575
Abstract: Summary I-motifs are noncanonical four-stranded DNA structures formed by C-rich sequences at acidic environment with critical biofunctions. The particular pH sensitivity has inspired the development of i-motifs as pH sensors and DNA motors in nanotechnology.… read more here.
Keywords: dna; acidic environment; conformational dynamics; remodeling conformational ... See more keywords
Early Folding Dynamics of i-Motif DNA Revealed by pH-Jump Time-Resolved X-ray Solution Scattering.
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DOI: 10.1021/jacs.4c11768
Abstract: The i-motif is a pH-responsive cytosine-rich oligonucleotide sequence that forms, under acidic conditions, a quadruplex structure. This tunable structural switching has made the i-motif a useful platform for designing pH-responsive nanomaterials. Despite the widespread application… read more here.
Keywords: time; jump; early folding; dynamics motif ... See more keywords