Evolutionary dynamics of neoantigens in growing tumors
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DOI: 10.1038/s41588-020-0687-1
Abstract: Cancers accumulate mutations that lead to neoantigens, novel peptides that elicit an immune response, and consequently undergo evolutionary selection. Here we establish how negative selection shapes the clonality of neoantigens in a growing cancer by… read more here.
Keywords: negative selection; dynamics neoantigens; selection; immune escape ... See more keywords