Dynamics of Substrate Processing by PPIP5K2, a Versatile Catalytic Machine.
Sign Up to like & getrecommendations! Published in 2019 at "Structure"
DOI: 10.1016/j.str.2019.03.007
Abstract: Processing of substrates by enzymes can only be fully understood through their conformational dynamics; this is particularly true for the diphosphoinositol pentakisphosphate kinase PPIP5K2, an enzyme with critical roles in cell signaling and bioenergetic homeostasis.… read more here.
Keywords: ppip5k2; processing ppip5k2; versatile catalytic; dynamics substrate ... See more keywords
Cooperative Ionic Coordination Governs Dopamine Transporter Dynamics and Substrate Translocation: Mechanistic Insights from Molecular Simulations.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.5c02156
Abstract: The dopamine transporter (DAT) plays a vital role in maintaining dopamine (DA) homeostasis by mediating the reuptake of DA from the synaptic cleft into presynaptic neurons, a process tightly coupled to the cotransport of two… read more here.
Keywords: transporter dynamics; mechanistic insights; substrate translocation; dynamics substrate ... See more keywords
Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome
Sign Up to like & getrecommendations! Published in 2018 at "Nature"
DOI: 10.1038/s41586-018-0736-4
Abstract: The proteasome is an ATP-dependent, 2.5-megadalton molecular machine that is responsible for selective protein degradation in eukaryotic cells. Here we present cryo-electron microscopy structures of the substrate-engaged human proteasome in seven conformational states at 2.8–3.6 Å… read more here.
Keywords: engaged human; microscopy; substrate engaged; structures dynamics ... See more keywords