Conformational Rearrangement of Fission DSPs
Sign Up to like & getrecommendations! Published in 2025 at "Bioessays"
DOI: 10.1002/bies.70062
Abstract: Dynamin superfamily proteins (DSPs) are large GTPases that play crucial roles in membrane remodeling processes, including vesicle uptake, mitochondrial fission, and opposing fusion events. Among them, dynamin and dynamin‐related protein 1 (Drp1) share a conserved… read more here.
Keywords: rearrangement fission; fission; dynamin; fission dsps ... See more keywords
Dynamin‐2 regulates microtubule stability via an endocytosis‐independent mechanism
Sign Up to like & getrecommendations! Published in 2022 at "Cytoskeleton"
DOI: 10.1002/cm.21723
Abstract: Microtubule stability and dynamics regulations are essential for vital cellular processes, such as microtubule‐dependent axonal transport. Dynamin is involved in many membrane fission events, such as clathrin‐mediated endocytosis. The ubiquitously expressed dynamin‐2 has been reported… read more here.
Keywords: endocytosis; dynamin; microtubule stability; heterozygous cells ... See more keywords
Cellular Assays for Measuring Dynamin Activity in Muscle Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0676-6_13
Abstract: Dynamin is one of the best-studied membrane fission machineries, which mediates endocytic vesicle pinch-off from the plasma membrane. Among the three dynamin isoforms encoded in mammalian genome, dynamin-2 is the ubiquitously expressed isoform and leads… read more here.
Keywords: cellular assays; measuring dynamin; dynamin activity; dynamin ... See more keywords
Dynamin 1 controls vesicle size and endocytosis at hippocampal synapses.
Sign Up to like & getrecommendations! Published in 2022 at "Cell calcium"
DOI: 10.1016/j.ceca.2022.102564
Abstract: Following calcium-triggered vesicle exocytosis, endocytosis regenerates vesicles to maintain exocytosis and thus synaptic transmission, which underlies neuronal circuit activities. Although most molecules involved in endocytosis have been identified, it remains rather poorly understood how endocytic… read more here.
Keywords: size; endocytosis; vesicle size; hippocampal synapses ... See more keywords
Dynamin-2 mutations linked to Centronuclear Myopathy impair actin-dependent trafficking in muscle cells
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-04418-w
Abstract: Dynamin-2 is a ubiquitously expressed GTP-ase that mediates membrane remodeling. Recent findings indicate that dynamin-2 also regulates actin dynamics. Mutations in dynamin-2 cause dominant centronuclear myopathy (CNM), a congenital myopathy characterized by progressive weakness and… read more here.
Keywords: muscle; dynamin mutations; muscle cells; centronuclear myopathy ... See more keywords
Exon skipping peptide-conjugated morpholinos downregulate dynamin 2 to rescue centronuclear myopathy
Sign Up to like & getrecommendations! Published in 2025 at "Brain"
DOI: 10.1093/brain/awaf249
Abstract: Abstract Centronuclear myopathies (CNM) are rare congenital disorders characterized by muscle weakness and disorganization of myofibres. These conditions can result from dominant mutations in the DNM2 gene encoding the GTPase dynamin, making them potential targets… read more here.
Keywords: exon skipping; muscle; protein; peptide conjugated ... See more keywords
Abstract 4140151: Network Analysis of Differentially Expressed Genes after Silencing Dynamin 2 in Pulmonary Arterial Hypertension
Sign Up to like & getrecommendations! Published in 2024 at "Circulation"
DOI: 10.1161/circ.150.suppl_1.4140151
Abstract: Rationale: Pulmonary arterial hypertension (PAH) is a rare cardiopulmonary disease that can cause right heart failure and even death. In PAH, excessive mitochondrial fission is responsible for the hyperproliferation of pulmonary artery smooth muscle cells… read more here.
Keywords: pah; dnm2; fission; analysis ... See more keywords
BIN1, Myotubularin, and Dynamin-2 Coordinate T-Tubule Growth in Cardiomyocytes
Sign Up to like & getrecommendations! Published in 2023 at "Circulation Research"
DOI: 10.1161/circresaha.122.321732
Abstract: Background: Transverse tubules (t-tubules) form gradually in the developing heart, critically enabling maturation of cardiomyocyte Ca2+ homeostasis. The membrane bending and scaffolding protein BIN1 (bridging integrator 1) has been implicated in this process. However, it… read more here.
Keywords: bin1; growth cardiomyocytes; dynamin; tubule growth ... See more keywords
SNX18 regulates ATG9A trafficking from recycling endosomes by recruiting Dynamin‐2
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DOI: 10.15252/embr.201744837
Abstract: Trafficking of mammalian ATG9A between the Golgi apparatus, endosomes and peripheral ATG9A compartments is important for autophagosome biogenesis. Here, we show that the membrane remodelling protein SNX18, previously identified as a positive regulator of autophagy,… read more here.
Keywords: recycling endosomes; snx18; regulates atg9a; atg9a trafficking ... See more keywords
Dynamin Autonomously Regulates Podocyte Focal Adhesion Maturation.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2016010008
Abstract: Rho family GTPases, the prototypical members of which are Cdc42, Rac1, and RhoA, are molecular switches best known for regulating the actin cytoskeleton. In addition to the canonical small GTPases, the large GTPase dynamin has… read more here.
Keywords: focal adhesion; regulating actin; adhesion maturation; dynamin ... See more keywords
Distinct functions of dynamin isoforms in tumorigenesis and their potential as therapeutic targets in cancer
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.16678
Abstract: Dynamins and their related proteins participate in the regulation of neurotransmission, antigen presentation, receptor internalization, growth factor signalling, nutrient uptake, and pathogen infection. Recently, emerging findings have shown dynamin proteins can also contribute to the… read more here.
Keywords: functions dynamin; therapeutic targets; distinct functions; targets cancer ... See more keywords