Ciliary dynein arms: Cytoplasmic preassembly, intraflagellar transport, and axonemal docking
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30689
Abstract: The microtubular scaffold of motile cilia—the axoneme, is decorated with dynein arms, which are large multiprotein complexes essential for ciliary motility. Dynein arms are arranged along the length of the axoneme in a precise repeating… read more here.
Keywords: intraflagellar transport; dynein arms; preassembly intraflagellar; cytoplasmic preassembly ... See more keywords
Dynein's Direction-Dependent Microtubule-Binding Strength is Controlled via a Tension-Induced Sliding of Dynein's Stalk Helices Mediated by the Coiled-Coil Strut
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.051
Abstract: Cytoskeletal motor protein motility requires coordination of ATPase and filament-binding cycles. Mechanical tension strongly influences these processes, and likely regulates motor stepping as external forces resist motor movement and intramolecular tension develops between motor domains.… read more here.
Keywords: tension; stalk helices; dynein; binding strength ... See more keywords
Dynarrestin, a Novel Inhibitor of Cytoplasmic Dynein.
Sign Up to like & getrecommendations! Published in 2018 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2017.12.014
Abstract: Aberrant hedgehog (Hh) signaling contributes to the pathogenesis of multiple cancers. Available inhibitors target Smoothened (Smo), which can acquire mutations causing drug resistance. Thus, compounds that inhibit Hh signaling downstream of Smo are urgently needed.… read more here.
Keywords: inhibitor cytoplasmic; dynein; novel inhibitor; cytoplasmic dynein ... See more keywords
Continuum Mechanical Parameterisation of Cytoplasmic Dynein from Atomistic Simulation.
Sign Up to like & getrecommendations! Published in 2020 at "Methods"
DOI: 10.1016/j.ymeth.2020.01.021
Abstract: Cytoplasmic dynein is responsible for intra-cellular transport in eukaryotic cells. Using Fluctuating Finite Element Analysis (FFEA), a novel algorithm that represents proteins as continuum viscoelastic solids subject to thermal noise, we are building computational tools… read more here.
Keywords: dynein; dynein atomistic; mechanical parameterisation; continuum mechanical ... See more keywords
Life and Work of Stress Granules and Processing Bodies: New Insights into Their Formation and Function.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b00025
Abstract: The dynamic formation of stress granules (SGs), processing bodies (PBs), and related RNA organelles regulates diverse cellular processes, including the coordination of functionally connected messengers, the translational regulation at the synapse, and the control of… read more here.
Keywords: stress granules; processing bodies; dynein; formation ... See more keywords
Computational modeling of dynein motor proteins at work.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc05857b
Abstract: Along with various experimental methods, a combination of theoretical and computational methods is essential to explore different length-scale and time-scale processes in the biological system. The functional mechanism of a dynein, an ATP-fueled motor protein,… read more here.
Keywords: motor proteins; computational modeling; mechanochemical cycle; dynein ... See more keywords
Loss of dynein‐2 intermediate chain Wdr34 results in defects in retrograde ciliary protein trafficking and Hedgehog signaling in the mouse
Sign Up to like & getrecommendations! Published in 2017 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddx127
Abstract: Abstract The Wdr34 gene encodes an intermediate chain of cytoplasmic dynein 2, the motor for retrograde intraflagellar transport (IFT) in primary cilia. Although mutations in human WDR34 have recently been reported, the association of WDR34… read more here.
Keywords: chain; intermediate chain; hedgehog signaling; dynein ... See more keywords
Dynll1 is essential for development and promotes endochondral bone formation by regulating intraflagellar Dynein function in primary cilia.
Sign Up to like & getrecommendations! Published in 2019 at "Human molecular genetics"
DOI: 10.1093/hmg/ddz083
Abstract: Mutations in subunits of the cilia-specific cytoplasmic Dynein-2 (CD2) complex cause short-rib thoracic dystrophy syndromes (SRTDs), characterized by impaired bone growth and life-threatening perinatal respiratory complications. Different SRTD mutations result in varying disease severities. It… read more here.
Keywords: cd2; dynein; bone; mice ... See more keywords
Chlamydomonas WDR92 in association with R2TP-like complex and multiple DNAAFs to regulate ciliary dynein preassembly
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjy067
Abstract: Abstract The motility of cilia or eukaryotic flagella is powered by the axonemal dyneins, which are preassembled in the cytoplasm by proteins termed dynein arm assembly factors (DNAAFs) before being transported to and assembled on… read more here.
Keywords: r2tp like; dynein; like complex; dynein preassembly ... See more keywords
A mathematical understanding of how cytoplasmic dynein walks on microtubules
Sign Up to like & getrecommendations! Published in 2018 at "Royal Society Open Science"
DOI: 10.1098/rsos.171568
Abstract: Cytoplasmic dynein 1 (hereafter referred to simply as dynein) is a dimeric motor protein that walks and transports intracellular cargos towards the minus end of microtubules. In this article, we formulate, based on physical principles,… read more here.
Keywords: walks microtubules; dynein; model; dynein walks ... See more keywords
The KASH5 protein involved in meiotic chromosomal movements is a novel dynein activating adaptor
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.03.11.483947
Abstract: Dynein harnesses ATP hydrolysis to move cargo on microtubules in multiple biological contexts. Dynein meets a unique challenge in meiosis by moving chromosomes tethered to the nuclear envelope to facilitate homolog pairing essential for gametogenesis.… read more here.
Keywords: dynein activating; activating adaptor; dynein; kash5 ... See more keywords