Articles with "dynein dynactin" as a keyword



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Hexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisions

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Published in 2019 at "Nature Communications"

DOI: 10.1038/s41467-019-09999-w

Abstract: Cortical force generators connect epithelial polarity sites with astral microtubules, allowing dynein movement to orient the mitotic spindle as astral microtubules depolymerize. Complexes of the LGN and NuMA proteins, fundamental components of force generators, are… read more here.

Keywords: dynein dynactin; numa lgn; cortical force; lgn ... See more keywords
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RUFY3 and RUFY4 are ARL8 effectors that promote coupling of endolysosomes to dynein-dynactin.

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Published in 2022 at "Nature communications"

DOI: 10.1038/s41467-022-28952-y

Abstract: The small GTPase ARL8 associates with endolysosomes, leading to the recruitment of several effectors that couple endolysosomes to kinesins for anterograde transport along microtubules, and to tethering factors for eventual fusion with other organelles. Herein… read more here.

Keywords: arl8 effectors; effectors promote; dynein dynactin; rufy3 rufy4 ... See more keywords
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Spindly is required for rapid migration of human cells

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Published in 2018 at "Biology Open"

DOI: 10.1242/bio.033233

Abstract: ABSTRACT Dynein is the sole processive minus-end-directed microtubule motor found in animals. It has roles in cell division, membrane trafficking, and cell migration. Together with dynactin, dynein regulates centrosomal orientation to establish and maintain cell… read more here.

Keywords: dynein dynactin; cell migration; migration;

The role of microtubules and the dynein/dynactin motor complex of host cells in the biogenesis of the Coxiella burnetii-containing vacuole

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Published in 2019 at "PLoS ONE"

DOI: 10.1371/journal.pone.0209820

Abstract: Microtubules (Mts) are dynamic cytoskeleton structures that play a key role in vesicular transport. The Mts-mediated transport depends on motor proteins named kinesins and the dynein/dynactin motor complex. The Rab7 adapter protein FYCO1 controls the… read more here.

Keywords: dynein dynactin; ccv; transport; role ... See more keywords