Transient Tertiary Structures of Disordered Dynein Intermediate Chain Regulate its Interactions with Multiple Partners.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2021.167152
Abstract: The N-terminal domain of dynein intermediate chain (N-IC) is central to the cytoplasmic dynein 'cargo attachment subcomplex' and regulation of motor activity. It is a prototypical intrinsically disordered protein (IDP), serving as a primarily disordered… read more here.
Keywords: transient tertiary; intermediate chain; p150glued nude; dynein intermediate ... See more keywords
Multivalency, autoinhibition, and protein disorder in the regulation of interactions of dynein intermediate chain with dynactin and the nuclear distribution protein
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.06.05.494868
Abstract: Cytoplasmic dynein plays crucial roles in the intracellular transport of organelles and other cargoes. Central to dynein function is the intrinsically disordered N-terminal domain of dynein intermediate chain (IC), which binds the three dimeric dynein… read more here.
Keywords: intermediate chain; distribution protein; nuclear distribution; autoinhibition ... See more keywords