Dynein light chain LC8 alleviates nonalcoholic steatohepatitis by inhibiting NF‐κB signaling and reducing oxidative stress
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30811
Abstract: Nonalcoholic steatohepatitis (NASH) is a liver disease characterized by fat accumulation and chronic inflammation in the liver. Dynein light chain of 8 kDa (LC8) was identified previously as an inhibitor of nuclear factor kappa B (NF‐κB),… read more here.
Keywords: mcd diet; dynein light; oxidative stress; mice ... See more keywords
Dynein light intermediate chains as pivotal determinants of dynein multifunctionality.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cell science"
DOI: 10.1242/jcs.254870
Abstract: In animal cells, a single cytoplasmic dynein motor mediates microtubule minus-end-directed transport, counterbalancing dozens of plus-end-directed kinesins. The remarkable ability of dynein to interact with a diverse cargo spectrum stems from its tightly regulated recruitment… read more here.
Keywords: chains pivotal; dynein; light intermediate; intermediate chains ... See more keywords
Novel linear motif filtering protocol reveals the role of the LC8 dynein light chain in the Hippo pathway
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1005885
Abstract: Protein-protein interactions (PPIs) formed between short linear motifs and globular domains play important roles in many regulatory and signaling processes but are highly underrepresented in current protein-protein interaction databases. These types of interactions are usually… read more here.
Keywords: protein; lc8; filtering protocol; motif ... See more keywords
Dynein Light Chain Protein Tctex1: A Novel Prognostic Marker and Molecular Mediator in Glioblastoma
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13112624
Abstract: Simple Summary Glioblastoma (GBM) remains one of the deadliest solid cancers, with only a dismal proportion of GBM patients achieving 5-year survival. Thus, it is critical to identify molecular mechanisms that could be targeted by… read more here.
Keywords: protein; glioblastoma; gbm; prognostic marker ... See more keywords