MicroRNA-1246 suppresses the metastasis of breast cancer cells by targeting the DYRK1A/PGRN axis to prevent the epithelial-mesenchymal transition.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular biology reports"
DOI: 10.1007/s11033-021-07080-8
Abstract: OBJECTIVE Breast cancer is one of the most common malignant and highly heterogeneous tumors in women. MicroRNAs (miRNAs), such as miR-1246, play important roles in various types of malignant cancers, including triple-negative breast cancer (TNBC).… read more here.
Keywords: mir; breast cancer; mir 1246; pgrn ... See more keywords
Identification of a DYRK1A-mediated phosphorylation site within the nuclear localization sequence of the hedgehog transcription factor GLI1.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.07.107
Abstract: GLI1 is a key downstream transcription effector of the Hedgehog (Hh) signaling pathway that is involved in promoting cell growth, differentiation and tissue patterning in embryonic development. GLI1 over-activation and its nuclear localization has also… read more here.
Keywords: localization sequence; nuclear localization; gli1; site ... See more keywords
Novel selective thiadiazine DYRK1A inhibitor lead scaffold with human pancreatic β-cell proliferation activity.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.08.007
Abstract: The Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A (DYRK1A) is an enzyme that has been implicated as an important drug target in various therapeutic areas, including neurological disorders (Down syndrome, Alzheimer's disease), oncology, and diabetes (pancreatic β-cell… read more here.
Keywords: dyrk1a; pancreatic cell; dyrk1a inhibitor; thiadiazine ... See more keywords
Design, synthesis and biological evaluation of harmine derivatives as potent GSK-3β/DYRK1A dual inhibitors for the treatment of Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113554
Abstract: Alzheimer's disease (AD) is a chronic and progressive neurodegenerative disease, characterized by irreversible cognitive impairment, memory loss and behavioral disturbances, ultimately leading to death. Glycogen synthase kinase 3β (GSK-3β) and dual-specificity tyrosine phosphorylation regulated kinase1A… read more here.
Keywords: alzheimer disease; dyrk1a; gsk dyrk1a; harmine derivatives ... See more keywords
Human cytomegalovirus utilises cellular dual-specificity tyrosine phosphorylation-regulated kinases during placental replication.
Sign Up to like & getrecommendations! Published in 2018 at "Placenta"
DOI: 10.1016/j.placenta.2018.10.002
Abstract: INTRODUCTION Congenital cytomegalovirus (HCMV) infection may cause significant fetal malformation and in severe cases fetal and neonatal death. Fetal injury may be caused indirectly by the placental response to infection. Dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs)… read more here.
Keywords: dual specificity; specificity tyrosine; hcmv; dyrk1a ... See more keywords
A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-42445-x
Abstract: Dysregulation of the DYRK1A protein kinase has been associated with human disease. On the one hand, its overexpression in trisomy 21 has been linked to certain pathological traits of Down syndrome, while on the other,… read more here.
Keywords: dna damage; damage response; kinase; interaction ... See more keywords
A complex between DYRK1A and DCAF7 phosphorylates the C-terminal domain of RNA polymerase II to promote myogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz162
Abstract: Abstract The general transcription factor P-TEFb, a master regulator of RNA polymerase (Pol) II elongation, phosphorylates the C-terminal domain (CTD) of Pol II and negative elongation factors to release Pol II from promoter-proximal pausing. We… read more here.
Keywords: terminal domain; dcaf7; rna polymerase; phosphorylates terminal ... See more keywords
Inhibition of DYRK1a Enhances Cardiomyocyte Cycling After Myocardial Infarction
Sign Up to like & getrecommendations! Published in 2022 at "Circulation Research"
DOI: 10.1161/circresaha.121.320005
Abstract: Background: DYRK1a (dual-specificity tyrosine phosphorylation-regulated kinase 1a) contributes to the control of cycling cells, including cardiomyocytes. However, the effects of inhibition of DYRK1a on cardiac function and cycling cardiomyocytes after myocardial infarction (MI) remain unknown.… read more here.
Keywords: inhibition dyrk1a; dyrk1a; cre fucci2ar; mhc cre ... See more keywords
Functional characterization of DYRK1A missense variants associated with a syndromic form of intellectual deficiency and autism
Sign Up to like & getrecommendations! Published in 2018 at "Biology Open"
DOI: 10.1242/bio.032862
Abstract: ABSTRACT Haploinsufficiency of DYRK1A is a cause of a neurodevelopmental syndrome termed mental retardation autosomal dominant 7 (MRD7). Several truncation mutations, microdeletions and missense variants have been identified and result in a recognizable phenotypic profile,… read more here.
Keywords: missense variants; autism; dyrk1a; activity ... See more keywords
Disruption of DYRK1A-induced hyperphosphorylation of amyloid-beta and tau protein in Alzheimer’s disease: An integrative molecular modeling approach
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.1078987
Abstract: Alzheimer’s disease (AD) is a neurological disorder caused by the abnormal accumulation of hyperphosphorylated proteins. Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a dual phosphorylation enzyme which phosphorylates the amyloid-β (Aβ) and neurofibrillary tangles (NFTs).… read more here.
Keywords: alzheimer disease; dyrk1a; analysis; kcal mol ... See more keywords
Proteomic profiling reveals mitochondrial dysfunction in the cerebellum of transgenic mice overexpressing DYRK1A, a Down syndrome candidate gene
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.1015220
Abstract: Introduction DYRK1A is a dual-specificity kinase that is overexpressed in Down syndrome (DS) and plays a key role in neurogenesis, neuronal differentiation and function, cognitive phenotypes, and aging. Dyrk1A has also been implicated in cerebellar… read more here.
Keywords: cerebellum transgenic; proteomic profiling; dyrk1a; transgenic mice ... See more keywords