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Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c02050
Abstract: According to the World Health Organization (WHO), 422 million people are suffering from diabetes worldwide. Current diabetes therapies are focused on optimizing blood glucose control to prevent long-term diabetes complications. Unfortunately, current therapies have failed…
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Keywords:
therapeutics cell;
cell proliferation;
potential therapeutics;
regeneration ... See more keywords
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Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0285208
Abstract: The decreased β-cell mass and impaired β-cell functionality are the primary causes of diabetes mellitus (DM). Nevertheless, the underlying molecular mechanisms by which β-cell growth and function are controlled are not fully understood. In this…
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Keywords:
cell;
isolated mouse;
mouse islets;
dyrk1a inhibitors ... See more keywords
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Published in 2022 at "Metabolites"
DOI: 10.3390/metabo13010051
Abstract: The pathogenesis of diabetes mellitus is characterized by insulin resistance and islet β-cell dysfunction. Up to now, the focus of diabetes treatment has been to control blood glucose to prevent diabetic complications. There is an…
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Keywords:
cell;
pancreatic cells;
diabetes therapeutics;
natural dyrk1a ... See more keywords